{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Suzuki H"],"pubmed_abstract":["<h4>Background</h4>Podoplanin, a mucin-like transmembrane glycoprotein, is reportedly expressed in a variety of malignant cells and is generally regarded as a factor for promoting tumor progression in conventional studies. By contrast, a clinicopathologically conflicting role for podoplanin, namely as a favorable prognostic factor for patients with lung/cervical squamous cell carcinoma (SCC), has recently been reported. Here, we investigated the role of podoplanin expressed in lung squamoid cancer cells (LSCCs) in experimental tumor progression.<h4>Results</h4>Using EBC-1 cells, a lung SCC cell line without podoplanin expression and with lymphogenous metastatic potential, stable transformants with or without an exogenous human podoplanin gene were established and applied to a mouse tumor i"],"journal":["Molecular cancer"],"pagination":["287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2987985"],"repository":["biostudies-literature"],"pubmed_title":["Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells."],"pmcid":["PMC2987985"],"pubmed_authors":["Maehara Y","Yonemitsu Y","Onimaru M","Sueishi K","Nakamura S","Suzuki H"],"additional_accession":[]},"is_claimable":false,"name":"Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells.","description":"<h4>Background</h4>Podoplanin, a mucin-like transmembrane glycoprotein, is reportedly expressed in a variety of malignant cells and is generally regarded as a factor for promoting tumor progression in conventional studies. By contrast, a clinicopathologically conflicting role for podoplanin, namely as a favorable prognostic factor for patients with lung/cervical squamous cell carcinoma (SCC), has recently been reported. Here, we investigated the role of podoplanin expressed in lung squamoid cancer cells (LSCCs) in experimental tumor progression.<h4>Results</h4>Using EBC-1 cells, a lung SCC cell line without podoplanin expression and with lymphogenous metastatic potential, stable transformants with or without an exogenous human podoplanin gene were established and applied to a mouse tumor i","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Oct","modification":"2025-04-05T00:26:56.35Z","creation":"2019-03-27T00:36:47Z"},"accession":"S-EPMC2987985","cross_references":{"pubmed":["21034514"],"doi":["10.1186/1476-4598-9-287"]}}