{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krow GR"],"funding":["NCRR NIH HHS","NIAMS NIH HHS"],"pagination":["5438-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2993784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(23)"],"pubmed_abstract":["CD spectra for homooligomers (n = 4, 6, 8) of (1S,4R,5R)-5-syn-carboxy-2-azabicyclo[2.1.1]hexane (MPCA), a methano-bridged pyrrolidine β-carboxylic acid, suggest an ordered secondary structure. Even in the absence of internal hydrogen bonding, solution NMR, X-ray, and in silico analyses of the tetramer are indicative of conformations with trans-amides and C(5)-amide-carbonyls oriented toward the C(4) bridgehead. This highly constrained β-amino acid could prove useful in the ongoing development of well-defined foldamers."],"journal":["Organic letters"],"pubmed_title":["Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order."],"pmcid":["PMC2993784"],"funding_grant_id":["S10 RR013790-01","R01 AR044276","R01 AR044276-15","AR044276","S10 RR13790","S10 RR013790"],"pubmed_authors":["DeBrosse C","Krow GR","Sonnet PE","Raines RT","Centafont R","Ross CW","Liu N","Shoulders MD","Lin G","Carroll PJ","Sender M"],"additional_accession":[]},"is_claimable":false,"name":"Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order.","description":"CD spectra for homooligomers (n = 4, 6, 8) of (1S,4R,5R)-5-syn-carboxy-2-azabicyclo[2.1.1]hexane (MPCA), a methano-bridged pyrrolidine β-carboxylic acid, suggest an ordered secondary structure. Even in the absence of internal hydrogen bonding, solution NMR, X-ray, and in silico analyses of the tetramer are indicative of conformations with trans-amides and C(5)-amide-carbonyls oriented toward the C(4) bridgehead. This highly constrained β-amino acid could prove useful in the ongoing development of well-defined foldamers.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Dec","modification":"2025-04-26T05:23:27.984Z","creation":"2019-03-27T00:37:02Z"},"accession":"S-EPMC2993784","cross_references":{"pubmed":["21043445"],"doi":["10.1021/ol1022917"]}}