{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rahman MM"],"funding":["NIDDK NIH HHS"],"pagination":["678-90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2993798"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(10)"],"pubmed_abstract":["O-linked-β-N-acetylglucosamine (O-GlcNAc) modification is a regulatory, nuclear and cytoplasmic post-translational glycosylation of proteins associated with age-related diseases such as Alzheimer's, Parkinson's, and type II diabetes. Global elevation of O-GlcNAc levels on intracellular proteins can induce insulin resistance, the hallmark of type II diabetes, in mammalian systems. InC. elegans, attenuation of the insulin-like signal transduction pathway increases adult lifespan of the nematode. We demonstrate that the O-GlcNAc cycling enzymes OGT and OGA, which add and remove O-GlcNAc respectively, modulate lifespan in C. elegans. Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nema"],"journal":["Aging"],"pubmed_title":["Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans."],"pmcid":["PMC2993798"],"funding_grant_id":["R01DK075069","R01 DK075069"],"pubmed_authors":["Rahman MM","El-Karim EG","Stuart R","Stuchlick O","Kipreos ET","Wells L"],"additional_accession":[]},"is_claimable":false,"name":"Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.","description":"O-linked-β-N-acetylglucosamine (O-GlcNAc) modification is a regulatory, nuclear and cytoplasmic post-translational glycosylation of proteins associated with age-related diseases such as Alzheimer's, Parkinson's, and type II diabetes. Global elevation of O-GlcNAc levels on intracellular proteins can induce insulin resistance, the hallmark of type II diabetes, in mammalian systems. InC. elegans, attenuation of the insulin-like signal transduction pathway increases adult lifespan of the nematode. We demonstrate that the O-GlcNAc cycling enzymes OGT and OGA, which add and remove O-GlcNAc respectively, modulate lifespan in C. elegans. Median adult lifespan is increased in an oga-1 deletion strain while median adult life span is decreased upon ogt-1 deletion. The O-GlcNAc-mediated effect on nema","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Oct","modification":"2025-04-26T05:23:35.527Z","creation":"2019-03-27T00:37:00Z"},"accession":"S-EPMC2993798","cross_references":{"pubmed":["20952811"],"doi":["10.18632/aging.100208"]}}