{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paz-Filho G"],"funding":["NIDDK NIH HHS","NCRR NIH HHS"],"pagination":["1808-12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2998704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(13)"],"pubmed_abstract":["<h4>Background</h4>Leptin is a pleiotropic hormone produced mainly by the adipose tissue. Its most well-known effect is to regulate food intake and energy metabolism within the hypothalamus. More recently, several peripheral and extra-hypothalamic effects have been described, expanding leptin's actions far beyond energy balance.<h4>Aims</h4>To review the extra-hypothalamic effects of leptin and their possible clinical implications.<h4>Methods</h4>We did a PubMed search using the terms \"leptin\" AND \"brain\" AND \"neuron\" AND \"glial\", and selected the most relevant articles.<h4>Results</h4>In extra-hypothalamic sites, leptin has remarkable effects on neurogenesis, axon growth, synaptogenesis, denditric morphology, development of oligodendroglial cells, neuron excitability, neuroprotection and "],"journal":["International journal of clinical practice"],"pubmed_title":["The procognitive effects of leptin in the brain and their clinical implications."],"pmcid":["PMC2998704"],"funding_grant_id":["R01 DK058851","K24 RR016996"],"pubmed_authors":["Paz-Filho G","Licinio J","Wong ML"],"additional_accession":[]},"is_claimable":false,"name":"The procognitive effects of leptin in the brain and their clinical implications.","description":"<h4>Background</h4>Leptin is a pleiotropic hormone produced mainly by the adipose tissue. Its most well-known effect is to regulate food intake and energy metabolism within the hypothalamus. More recently, several peripheral and extra-hypothalamic effects have been described, expanding leptin's actions far beyond energy balance.<h4>Aims</h4>To review the extra-hypothalamic effects of leptin and their possible clinical implications.<h4>Methods</h4>We did a PubMed search using the terms \"leptin\" AND \"brain\" AND \"neuron\" AND \"glial\", and selected the most relevant articles.<h4>Results</h4>In extra-hypothalamic sites, leptin has remarkable effects on neurogenesis, axon growth, synaptogenesis, denditric morphology, development of oligodendroglial cells, neuron excitability, neuroprotection and ","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Dec","modification":"2025-04-05T09:57:13.356Z","creation":"2019-03-27T00:37:15Z"},"accession":"S-EPMC2998704","cross_references":{"pubmed":["21070531"],"doi":["10.1111/j.1742-1241.2010.02536.x"]}}