{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin HH"],"funding":["KCL start-up fund and a Taiwanese government (the Ministry of National Defense) fund","Medical Research Council","Charles Wolfson Charitable Trust","MRC Career Development Fellowship"],"pagination":["1950-60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3003906"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(11)"],"pubmed_abstract":["Neural induction is the first step in the formation of the vertebrate central nervous system. The emerging consensus of the mechanisms underlying neural induction is the combined influences from inhibiting bone morphogenetic protein (BMP) signaling and activating fibroblast growth factor (FGF)/Erk signaling, which act extrinsically via either autocrine or paracrine fashions. However, do intrinsic forces (cues) exist and do they play decisive roles in neural induction? These questions remain to be answered. Here, we have identified a novel neural initiator, neuronatin (Nnat), which acts as an intrinsic factor to promote neural fate in mammals and Xenopus. ESCs lacking this intrinsic factor fail to undergo neural induction despite the inhibition of the BMP pathway. We show that Nnat initiate"],"journal":["Stem cells (Dayton, Ohio)"],"pubmed_title":["Neuronatin promotes neural lineage in ESCs via Ca(2+) signaling."],"pmcid":["PMC3003906"],"funding_grant_id":["G0901899","G120/782"],"pubmed_authors":["Price J","Bates TJ","Lin HH","Uwanogho D","Perfect LW","Bell E","Sun YM","Snetkov V","Noristani H"],"additional_accession":[]},"is_claimable":false,"name":"Neuronatin promotes neural lineage in ESCs via Ca(2+) signaling.","description":"Neural induction is the first step in the formation of the vertebrate central nervous system. The emerging consensus of the mechanisms underlying neural induction is the combined influences from inhibiting bone morphogenetic protein (BMP) signaling and activating fibroblast growth factor (FGF)/Erk signaling, which act extrinsically via either autocrine or paracrine fashions. However, do intrinsic forces (cues) exist and do they play decisive roles in neural induction? These questions remain to be answered. Here, we have identified a novel neural initiator, neuronatin (Nnat), which acts as an intrinsic factor to promote neural fate in mammals and Xenopus. ESCs lacking this intrinsic factor fail to undergo neural induction despite the inhibition of the BMP pathway. We show that Nnat initiate","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Nov","modification":"2026-07-03T03:20:28.687Z","creation":"2019-03-27T00:37:28Z"},"accession":"S-EPMC3003906","cross_references":{"pubmed":["20872847"],"doi":["10.1002/stem.530"]}}