{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(12)"],"submitter":["Miao AJ"],"pubmed_abstract":["The behavior and toxicity of silver engineered nanoparticles (Ag-ENs) to the mixotrophic freshwater alga Ochromonas danica were examined in the present study to determine whether any other mechanisms are involved in their algal toxicity besides Ag(+) liberation outside the cells. Despite their good dispersability, the Ag-ENs were found to continuously aggregate and dissolve rapidly. When the initial nanoparticle concentration was lower than 10 µM, the total dissolved Ag(+) concentration ([Ag(+)](T)) in the suspending media reached its maximum after 1 d and then decreased suggesting that Ag(+) release might be limited by the nanoparticle surface area under these conditions. Furthermore, Ag-EN dissolution extent remarkably increased in the presence of glutathione. In the Ag-EN toxicity exper"],"journal":["PloS one"],"pagination":["e15196"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3008680"],"repository":["biostudies-literature"],"pubmed_title":["Intracellular uptake: a possible mechanism for silver engineered nanoparticle toxicity to a freshwater alga Ochromonas danica."],"pmcid":["PMC3008680"],"pubmed_authors":["Chin WC","Quigg A","Santschi PH","Luo Z","Miao AJ","Chen CS"],"additional_accession":[]},"is_claimable":false,"name":"Intracellular uptake: a possible mechanism for silver engineered nanoparticle toxicity to a freshwater alga Ochromonas danica.","description":"The behavior and toxicity of silver engineered nanoparticles (Ag-ENs) to the mixotrophic freshwater alga Ochromonas danica were examined in the present study to determine whether any other mechanisms are involved in their algal toxicity besides Ag(+) liberation outside the cells. Despite their good dispersability, the Ag-ENs were found to continuously aggregate and dissolve rapidly. When the initial nanoparticle concentration was lower than 10 µM, the total dissolved Ag(+) concentration ([Ag(+)](T)) in the suspending media reached its maximum after 1 d and then decreased suggesting that Ag(+) release might be limited by the nanoparticle surface area under these conditions. Furthermore, Ag-EN dissolution extent remarkably increased in the presence of glutathione. In the Ag-EN toxicity exper","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Dec","modification":"2026-05-29T10:52:36.003Z","creation":"2026-04-08T04:48:45.501Z"},"accession":"S-EPMC3008680","cross_references":{"pubmed":["21203552"],"doi":["10.1371/journal.pone.0015196"]}}