{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yuan C"],"funding":["Intramural NIH HHS","NEI NIH HHS"],"pagination":["33-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3016975"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Ceramidases catalyze the conversion of ceramide to sphingosine. They are acylaminohydrolases that catalyze the deacylation of the amide-linked saturated fatty acid from ceramide to generate sphingosine. They also catalyze the reverse reaction of ceramide biosynthesis using sphingosine and fatty acid. In mammals, different proteins catalyze these reactions while individually exhibiting optimal activity over a narrow pH range and have been accordingly called acid, neutral, and alkaline ceramidases. Several genes encode for variants of alkaline ceramidase in mammals. Brainwashing (Bwa) is the only putative alkaline ceramidase homologue present in Drosophila. In this study we have demonstrated that BWA does not exhibit ceramidase activity and that bwa null mutants display no loss of ceramidase"],"journal":["Molecular biology of the cell"],"pubmed_title":["CDase is a pan-ceramidase in Drosophila."],"pmcid":["PMC3016975"],"funding_grant_id":["R01 EY016469","R01EY16469"],"pubmed_authors":["Yuan C","Preat T","Fukusaki E","Jesmin N","Acharya JK","Acharya U","Rao RP","Nagashima K","Bamba T","Pascual A"],"additional_accession":[]},"is_claimable":false,"name":"CDase is a pan-ceramidase in Drosophila.","description":"Ceramidases catalyze the conversion of ceramide to sphingosine. They are acylaminohydrolases that catalyze the deacylation of the amide-linked saturated fatty acid from ceramide to generate sphingosine. They also catalyze the reverse reaction of ceramide biosynthesis using sphingosine and fatty acid. In mammals, different proteins catalyze these reactions while individually exhibiting optimal activity over a narrow pH range and have been accordingly called acid, neutral, and alkaline ceramidases. Several genes encode for variants of alkaline ceramidase in mammals. Brainwashing (Bwa) is the only putative alkaline ceramidase homologue present in Drosophila. In this study we have demonstrated that BWA does not exhibit ceramidase activity and that bwa null mutants display no loss of ceramidase","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan","modification":"2025-04-04T19:17:51.042Z","creation":"2019-03-27T00:37:53Z"},"accession":"S-EPMC3016975","cross_references":{"pubmed":["21148295"],"doi":["10.1091/mbc.E10-05-0453"]}}