{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kahn SR"],"funding":["Canadian Institutes of Health Research"],"pagination":["37-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3017252"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["183(1)"],"pubmed_abstract":["<h4>Background</h4>Exercise training may have the potential to improve post-thrombotic syndrome, a frequent, chronic complication of deep venous thrombosis. We conducted a randomized controlled two-centre pilot trial to assess the feasibility of a multicentre-based evaluation of a six-month exercise training program to treat post-thrombotic syndrome and to obtain preliminary data on the effectiveness of such a program.<h4>Methods</h4>Patients were randomized to receive exercise training (a six-month trainer-supervised program) or control treatment (an education session with monthly phone follow-ups). Levels of eligibility, consent, adherence and retention were used as indicators of study feasibility. Primary outcomes were change from baseline to six months in venous disease-specific quality of life (as measured using the Venous Insufficiency Epidemiological and Economic Study Quality of Life [VEINES-QOL] questionnaire) and severity of post-thrombotic syndrome (as measured by scores on the Villalta scale) in the exercise training group versus the control group, assessed by t tests. Secondary outcomes were change in generic quality of life (as measured using the Short-Form Health Survey-36 [SF-36] questionnaire), category of severity of post-thrombotic syndrome, leg strength, leg flexibility and time on treadmill.<h4>Results</h4>Of 95 patients with post-thrombotic syndrome, 69 were eligible, 43 consented and were randomized, and 39 completed the study. Exercise training was associated with improvement in VEINES-QOL scores (exercise training mean change 6.0, standard deviation [SD] 5.1 v. control mean change 1.4, SD 7.2; difference 4.6, 95% CI 0.54 to 8.7; p = 0.027) and improvement in scores on the Villalta scale (exercise training mean change -3.6, SD 3.7 v. control mean change -1.6, SD 4.3; difference -2.0, 95% CI -4.6 to 0.6; p = 0.14). Most secondary outcomes also showed greater improvement in the exercise training group.<h4>Interpretation</h4>Exercise training may improve post-thrombotic syndrome. It would be feasible to definitively evaluate exercise training as a treatment for post-thrombotic syndrome in a large multicentre trial."],"journal":["CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne"],"pubmed_title":["Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial."],"pmcid":["PMC3017252"],"funding_grant_id":["FRN 79846","MTC82338"],"pubmed_authors":["Kovacs MJ","Kearon C","Wells PS","Hirsch AM","Rodger MA","Anderson DR","Rabhi K","Kahn SR","Shapiro S","Houweling AH","Reid RD","Shrier I"],"additional_accession":[]},"is_claimable":false,"name":"Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial.","description":"<h4>Background</h4>Exercise training may have the potential to improve post-thrombotic syndrome, a frequent, chronic complication of deep venous thrombosis. We conducted a randomized controlled two-centre pilot trial to assess the feasibility of a multicentre-based evaluation of a six-month exercise training program to treat post-thrombotic syndrome and to obtain preliminary data on the effectiveness of such a program.<h4>Methods</h4>Patients were randomized to receive exercise training (a six-month trainer-supervised program) or control treatment (an education session with monthly phone follow-ups). Levels of eligibility, consent, adherence and retention were used as indicators of study feasibility. Primary outcomes were change from baseline to six months in venous disease-specific quality of life (as measured using the Venous Insufficiency Epidemiological and Economic Study Quality of Life [VEINES-QOL] questionnaire) and severity of post-thrombotic syndrome (as measured by scores on the Villalta scale) in the exercise training group versus the control group, assessed by t tests. Secondary outcomes were change in generic quality of life (as measured using the Short-Form Health Survey-36 [SF-36] questionnaire), category of severity of post-thrombotic syndrome, leg strength, leg flexibility and time on treadmill.<h4>Results</h4>Of 95 patients with post-thrombotic syndrome, 69 were eligible, 43 consented and were randomized, and 39 completed the study. Exercise training was associated with improvement in VEINES-QOL scores (exercise training mean change 6.0, standard deviation [SD] 5.1 v. control mean change 1.4, SD 7.2; difference 4.6, 95% CI 0.54 to 8.7; p = 0.027) and improvement in scores on the Villalta scale (exercise training mean change -3.6, SD 3.7 v. control mean change -1.6, SD 4.3; difference -2.0, 95% CI -4.6 to 0.6; p = 0.14). Most secondary outcomes also showed greater improvement in the exercise training group.<h4>Interpretation</h4>Exercise training may improve post-thrombotic syndrome. It would be feasible to definitively evaluate exercise training as a treatment for post-thrombotic syndrome in a large multicentre trial.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan","modification":"2021-02-20T21:42:27Z","creation":"2019-03-27T00:37:55Z"},"accession":"S-EPMC3017252","cross_references":{"pubmed":["21098066"],"doi":["10.1503/cmaj.100248"]}}