biostudies-literatureUnknown6(1)McLean MHColorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. Inflammatory activity within the stroma of invasive colorectal tumours is known to be a key predictor of disease activity with type, density and location of immune cells impacting on patient prognosis. To date, there has been no report of inflammatory phenotype within pre-malignant human colonic adenomas. Assessing the stromal microenvironment and particularly, inflammatory activity within colorectal neoplastic lesions is central to understanding early colorectal carcinogenesis. Inflammatory cell infiltrate was assessed by immunohistochemistry in paired colonic adenoma and adjacent normal colonic mucosa samples, and adenomas exhibiting increasing degrees of epithelial cell dysplasia. Macrophage phenotype was assPloS onee15366https://www.ebi.ac.uk/biostudies/studies/S-EPMC3017541biostudies-literatureThe inflammatory microenvironment in colorectal neoplasia.PMC3017541Mowat NAThomson JStewart KNHope MEl-Omar EMMcLean MHNorrie GMayer CHold GLFyfe NDrew JEMurray GIfalseThe inflammatory microenvironment in colorectal neoplasia.Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. Inflammatory activity within the stroma of invasive colorectal tumours is known to be a key predictor of disease activity with type, density and location of immune cells impacting on patient prognosis. To date, there has been no report of inflammatory phenotype within pre-malignant human colonic adenomas. Assessing the stromal microenvironment and particularly, inflammatory activity within colorectal neoplastic lesions is central to understanding early colorectal carcinogenesis. Inflammatory cell infiltrate was assessed by immunohistochemistry in paired colonic adenoma and adjacent normal colonic mucosa samples, and adenomas exhibiting increasing degrees of epithelial cell dysplasia. Macrophage phenotype was ass2011-01-01T00:00:00Z2011 Jan2025-04-04T19:18:34.957Z2019-03-26T23:09:17ZS-EPMC30175412124912410.1371/journal.pone.0015366