{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Balamurugan K"],"funding":["CCR NIH HHS","Intramural NIH HHS","NCI NIH HHS"],"pagination":["4106-17"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3018791"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(24)"],"pubmed_abstract":["Inflammation and hypoxia are known to promote the metastatic progression of tumours. The CCAAT/enhancer-binding protein-δ (C/EBPδ, CEBPD) is an inflammatory response gene and candidate tumour suppressor, but its physiological role in tumourigenesis in vivo is unknown. Here, we demonstrate a tumour suppressor function of C/EBPδ using transgenic mice overexpressing the Neu/Her2/ERBB2 proto-oncogene in the mammary gland. Unexpectedly, this study also revealed that C/EBPδ is necessary for efficient tumour metastasis. We show that C/EBPδ is induced by hypoxia in tumours in vivo and in breast tumour cells in vitro, and that C/EBPδ-deficient cells exhibit reduced glycolytic metabolism and cell viability under hypoxia. C/EBPδ supports CXCR4 expression. On the other hand, C/EBPδ directly inhibits e"],"journal":["The EMBO journal"],"pubmed_title":["The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis."],"pmcid":["PMC3018791"],"funding_grant_id":["HHSN261200800001E","HHSN261200800001C"],"pubmed_authors":["Sterneck E","Wang JM","Leighty R","Sharan S","Tsai HH","Balamurugan K","Anver M"],"additional_accession":[]},"is_claimable":false,"name":"The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis.","description":"Inflammation and hypoxia are known to promote the metastatic progression of tumours. The CCAAT/enhancer-binding protein-δ (C/EBPδ, CEBPD) is an inflammatory response gene and candidate tumour suppressor, but its physiological role in tumourigenesis in vivo is unknown. Here, we demonstrate a tumour suppressor function of C/EBPδ using transgenic mice overexpressing the Neu/Her2/ERBB2 proto-oncogene in the mammary gland. Unexpectedly, this study also revealed that C/EBPδ is necessary for efficient tumour metastasis. We show that C/EBPδ is induced by hypoxia in tumours in vivo and in breast tumour cells in vitro, and that C/EBPδ-deficient cells exhibit reduced glycolytic metabolism and cell viability under hypoxia. C/EBPδ supports CXCR4 expression. On the other hand, C/EBPδ directly inhibits e","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Dec","modification":"2025-04-26T05:09:07.032Z","creation":"2019-03-27T00:37:59Z"},"accession":"S-EPMC3018791","cross_references":{"pubmed":["21076392"],"doi":["10.1038/emboj.2010.280"]}}