biostudies-literatureUnknown108(2)Winkelmann RKrüppel-like factor 2 (KLF2) controls T lymphocyte egress from lymphoid organs by regulating sphingosin-1 phosphate receptor 1 (S1Pr1). Here we show that this is not the case for B cells. Instead, KLF2 controls homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of β(7)-integrin. In mice with a B cell-specific deletion of KLF2, S1Pr1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets including B1 cells were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring fewer B cells were found, and fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow weProceedings of the National Academy of Sciences of the United States of America710-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC3021026biostudies-literatureB cell homeostasis and plasma cell homing controlled by Kruppel-like factor 2.PMC3021026Jack HMSandrock LPorstner MReth MKahn MLSchuh WRoth EWinkelmann RHobeika EMathews MfalseB cell homeostasis and plasma cell homing controlled by Kruppel-like factor 2.Krüppel-like factor 2 (KLF2) controls T lymphocyte egress from lymphoid organs by regulating sphingosin-1 phosphate receptor 1 (S1Pr1). Here we show that this is not the case for B cells. Instead, KLF2 controls homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of β(7)-integrin. In mice with a B cell-specific deletion of KLF2, S1Pr1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets including B1 cells were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring fewer B cells were found, and fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow we2011-01-01T00:00:00Z2011 Jan2025-05-18T13:23:23.077Z2025-05-18T13:23:23.077ZS-EPMC30210262118740910.1073/pnas.1012858108