{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Siddique A"],"funding":["Wellcome Trust"],"pubmed_abstract":["Neisseria meningitidis is the primary causative agent of bacterial meningitis. The genome is rich in repetitive DNA and almost 2% is occupied by a diminutive transposon called the Correia element. Here we report a bioinformatic analysis defining eight subtypes of the element with four distinct types of ends. Transcriptional analysis, using PCR and a lacZ reporter system, revealed that two ends in particular encode strong promoters. The activity of the strongest promoter is dictated by a recurrent polymorphism (Y128) at the right end of the element. We highlight examples of elements that appear to drive transcription of adjacent genes and others that may express small non-coding RNAs. Pair-wise comparisons between three meningococcal genomes revealed that no more than two-thirds of Correia "],"journal":["PLoS genetics"],"pagination":["e1001277"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3024310"],"repository":["biostudies-literature"],"pubmed_title":["The transposon-like Correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus."],"pmcid":["PMC3024310"],"pubmed_authors":["Buisine N","Chalmers R","Siddique A"],"additional_accession":[]},"is_claimable":false,"name":"The transposon-like Correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus.","description":"Neisseria meningitidis is the primary causative agent of bacterial meningitis. The genome is rich in repetitive DNA and almost 2% is occupied by a diminutive transposon called the Correia element. Here we report a bioinformatic analysis defining eight subtypes of the element with four distinct types of ends. Transcriptional analysis, using PCR and a lacZ reporter system, revealed that two ends in particular encode strong promoters. The activity of the strongest promoter is dictated by a recurrent polymorphism (Y128) at the right end of the element. We highlight examples of elements that appear to drive transcription of adjacent genes and others that may express small non-coding RNAs. Pair-wise comparisons between three meningococcal genomes revealed that no more than two-thirds of Correia ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan","modification":"2026-05-02T07:43:24.167Z","creation":"2019-03-27T00:38:18Z"},"accession":"S-EPMC3024310","cross_references":{"pubmed":["21283790"],"doi":["10.1371/journal.pgen.1001277"]}}