{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["55(2)"],"submitter":["Hilliard JJ"],"pubmed_abstract":["Doripenem is a carbapenem with potent broad-spectrum activity against Gram-negative pathogens, including antibiotic-resistant Enterobacteriaceae. As the incidence of extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli is increasing, it was of interest to examine the in vivo comparative efficacy of doripenem, imipenem, and meropenem against a Klebsiella pneumoniae isolate expressing the TEM-26 ESBL enzyme. In a murine lethal lower respiratory infection model, doripenem reduced the Klebsiella lung burden by 2 log(10) CFU/g lung tissue over the first 48 h of the infection. Treatment of mice with meropenem or imipenem yielded reductions of approximately 1.5 log(10) CFU/g during this time period. Seven days postinfection, Klebsiella titers in the lungs of treated mice decreased"],"journal":["Antimicrobial agents and chemotherapy"],"pagination":["836-44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3028822"],"repository":["biostudies-literature"],"pubmed_title":["Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model."],"pmcid":["PMC3028822"],"pubmed_authors":["Bunting RA","Barron A","Hall L","Fernandez J","Ward CK","Flamm RK","Hilliard JJ","Abbanat D","Melton JL","Lynch AS"],"additional_accession":[]},"is_claimable":false,"name":"Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model.","description":"Doripenem is a carbapenem with potent broad-spectrum activity against Gram-negative pathogens, including antibiotic-resistant Enterobacteriaceae. As the incidence of extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli is increasing, it was of interest to examine the in vivo comparative efficacy of doripenem, imipenem, and meropenem against a Klebsiella pneumoniae isolate expressing the TEM-26 ESBL enzyme. In a murine lethal lower respiratory infection model, doripenem reduced the Klebsiella lung burden by 2 log(10) CFU/g lung tissue over the first 48 h of the infection. Treatment of mice with meropenem or imipenem yielded reductions of approximately 1.5 log(10) CFU/g during this time period. Seven days postinfection, Klebsiella titers in the lungs of treated mice decreased","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Feb","modification":"2025-04-05T00:26:52.311Z","creation":"2019-03-27T00:38:27Z"},"accession":"S-EPMC3028822","cross_references":{"pubmed":["21135187"],"doi":["10.1128/AAC.00670-10","10.1128/aac.00670-10"]}}