biostudies-literatureUnknown55(2)Hilliard JJDoripenem is a carbapenem with potent broad-spectrum activity against Gram-negative pathogens, including antibiotic-resistant Enterobacteriaceae. As the incidence of extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli is increasing, it was of interest to examine the in vivo comparative efficacy of doripenem, imipenem, and meropenem against a Klebsiella pneumoniae isolate expressing the TEM-26 ESBL enzyme. In a murine lethal lower respiratory infection model, doripenem reduced the Klebsiella lung burden by 2 log(10) CFU/g lung tissue over the first 48 h of the infection. Treatment of mice with meropenem or imipenem yielded reductions of approximately 1.5 log(10) CFU/g during this time period. Seven days postinfection, Klebsiella titers in the lungs of treated mice decreasedAntimicrobial agents and chemotherapy836-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC3028822biostudies-literatureComparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model.PMC3028822Bunting RABarron AHall LFernandez JWard CKFlamm RKHilliard JJAbbanat DMelton JLLynch ASfalseComparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model.Doripenem is a carbapenem with potent broad-spectrum activity against Gram-negative pathogens, including antibiotic-resistant Enterobacteriaceae. As the incidence of extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli is increasing, it was of interest to examine the in vivo comparative efficacy of doripenem, imipenem, and meropenem against a Klebsiella pneumoniae isolate expressing the TEM-26 ESBL enzyme. In a murine lethal lower respiratory infection model, doripenem reduced the Klebsiella lung burden by 2 log(10) CFU/g lung tissue over the first 48 h of the infection. Treatment of mice with meropenem or imipenem yielded reductions of approximately 1.5 log(10) CFU/g during this time period. Seven days postinfection, Klebsiella titers in the lungs of treated mice decreased2011-01-01T00:00:00Z2011 Feb2025-04-05T00:26:52.311Z2019-03-27T00:38:27ZS-EPMC30288222113518710.1128/AAC.00670-1010.1128/aac.00670-10