{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["NIAID NIH HHS"],"pagination":["606-16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3028840"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(2)"],"pubmed_abstract":["During group B streptococcal infection, the alpha C protein (ACP) on the bacterial surface binds to host cell surface heparan sulfate proteoglycans (HSPGs) and facilitates entry of bacteria into human epithelial cells. Previous studies in a Drosophila melanogaster model showed that binding of ACP to the sulfated polysaccharide chains (glycosaminoglycans) of HSPGs promotes host death and is associated with higher bacterial burdens. We hypothesized that ACP-glycosaminoglycan binding might determine infection outcome by altering host responses to infection, such as expression of antimicrobial peptides. As glycosaminoglycans/HSPGs also interact with a number of endogenous secreted signaling molecules in Drosophila, we examined the effects of host and pathogen glycosaminoglycan/HSPG-binding str"],"journal":["Infection and immunity"],"pubmed_title":["Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses in Drosophila melanogaster."],"pmcid":["PMC3028840"],"funding_grant_id":["AI059495","U54 AI057159","AI057159","K08 AI059495"],"pubmed_authors":["Linhardt RJ","Kemp MM","Flax LA","Baron MJ","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses in Drosophila melanogaster.","description":"During group B streptococcal infection, the alpha C protein (ACP) on the bacterial surface binds to host cell surface heparan sulfate proteoglycans (HSPGs) and facilitates entry of bacteria into human epithelial cells. Previous studies in a Drosophila melanogaster model showed that binding of ACP to the sulfated polysaccharide chains (glycosaminoglycans) of HSPGs promotes host death and is associated with higher bacterial burdens. We hypothesized that ACP-glycosaminoglycan binding might determine infection outcome by altering host responses to infection, such as expression of antimicrobial peptides. As glycosaminoglycans/HSPGs also interact with a number of endogenous secreted signaling molecules in Drosophila, we examined the effects of host and pathogen glycosaminoglycan/HSPG-binding str","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Feb","modification":"2025-04-05T00:26:53.166Z","creation":"2019-03-27T00:38:27Z"},"accession":"S-EPMC3028840","cross_references":{"pubmed":["21078848"],"doi":["10.1128/iai.00254-10","10.1128/IAI.00254-10"]}}