biostudies-literatureNeess DLundbeck Foundation3460-72https://www.ebi.ac.uk/biostudies/studies/S-EPMC3030352biostudies-literatureUnknown286(5)The acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor is an intracellular protein that binds C(14)-C(22) acyl-CoA esters and is thought to act as an acyl-CoA transporter. In vitro analyses have indicated that ACBP can transport acyl-CoA esters between different enzymatic systems; however, little is known about the in vivo function in mammalian cells. We have generated mice with targeted disruption of ACBP (ACBP(-/-)). These mice are viable and fertile and develop normally. However, around weaning, the ACBP(-/-) mice go through a crisis with overall weakness and a slightly decreased growth rate. Using microarray analysis, we show that the liver of ACBP(-/-) mice displays a significantly delayed adaptation to weaning with late induction of target genes of the sterol regulatory elemeThe Journal of biological chemistryDisruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning.PMC3030352R7-2006-648Mandrup SElle ICPagmantidis VFærgeman NBek SFinsen BKruhoffer MBloksgaard MDue MNeess DWilbertz JMarcher ABHelledie TfalseDisruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning.The acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor is an intracellular protein that binds C(14)-C(22) acyl-CoA esters and is thought to act as an acyl-CoA transporter. In vitro analyses have indicated that ACBP can transport acyl-CoA esters between different enzymatic systems; however, little is known about the in vivo function in mammalian cells. We have generated mice with targeted disruption of ACBP (ACBP(-/-)). These mice are viable and fertile and develop normally. However, around weaning, the ACBP(-/-) mice go through a crisis with overall weakness and a slightly decreased growth rate. Using microarray analysis, we show that the liver of ACBP(-/-) mice displays a significantly delayed adaptation to weaning with late induction of target genes of the sterol regulatory eleme2011-01-01T00:00:00Z2011 Feb2025-04-05T10:56:26.484Z2019-06-06T22:37:41ZS-EPMC30303522110652710.1074/jbc.M110.16110910.1074/jbc.m110.161109