{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Garbacki N"],"pubmed_abstract":["<h4>Background</h4>miRNAs are now recognized as key regulator elements in gene expression. Although they have been associated with a number of human diseases, their implication in acute and chronic asthma and their association with lung remodelling have never been thoroughly investigated.<h4>Methodology/principal findings</h4>In order to establish a miRNAs expression profile in lung tissue, mice were sensitized and challenged with ovalbumin mimicking acute, intermediate and chronic human asthma. Levels of lung miRNAs were profiled by microarray and in silico analyses were performed to identify potential mRNA targets and to point out signalling pathways and biological processes regulated by miRNA-dependent mechanisms. Fifty-eight, 66 and 75 miRNAs were found to be significantly modulated at"],"journal":["PloS one"],"pagination":["e16509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3030602"],"repository":["biostudies-literature"],"pubmed_title":["MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets."],"pmcid":["PMC3030602"],"pubmed_authors":["Huynh-Thu VA","Crahay C","Irrthum A","Cataldo D","Geurts P","Deroanne C","Di Valentin E","Garbacki N","Piette J","Colige A","Arnould T"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets.","description":"<h4>Background</h4>miRNAs are now recognized as key regulator elements in gene expression. Although they have been associated with a number of human diseases, their implication in acute and chronic asthma and their association with lung remodelling have never been thoroughly investigated.<h4>Methodology/principal findings</h4>In order to establish a miRNAs expression profile in lung tissue, mice were sensitized and challenged with ovalbumin mimicking acute, intermediate and chronic human asthma. Levels of lung miRNAs were profiled by microarray and in silico analyses were performed to identify potential mRNA targets and to point out signalling pathways and biological processes regulated by miRNA-dependent mechanisms. Fifty-eight, 66 and 75 miRNAs were found to be significantly modulated at","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan","modification":"2025-04-04T19:42:51.798Z","creation":"2019-03-26T23:09:21Z"},"accession":"S-EPMC3030602","cross_references":{"pubmed":["21305051"],"doi":["10.1371/journal.pone.0016509"]}}