{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shaaban KA"],"funding":["NCI NIH HHS"],"pagination":["141-50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3030652"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(1)"],"pubmed_abstract":["Four new angucyclin(on)es, 11-deoxylandomycinone (1) and landomycins X-Z (2-4) were isolated from the crude extract of Streptomyces cyanogenus K62 mutant strain, along with the recently reported landomycins S, T and V (5-7) and five other known compounds. The structures of the new compounds 1-4 were elucidated by 1D and 2D NMR studies along with HR-MS analyses. Unique about the structures is that the fourth sugar moiety (sugar D) in landomycins X-Z (2-4) was β-D-amicetose instead of β-D-olivose, usually found in this position. The new angucyclin(on)es were biologically evaluated in comparison with previously known congeners against a small panel of MCF-7 (estrogen responsive) and MDA 231 (estrogen refractory) breast cancer cell lines. 11-deoxylandomycinone (IC(50) 2.1 ± 0.3 and 1.2 ± 0.4 μ"],"journal":["The Journal of antibiotics"],"pubmed_title":["11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain."],"pmcid":["PMC3030652"],"funding_grant_id":["R01 CA102102-05S1","CA 102102","R01 CA102102","R01 CA102102-05"],"pubmed_authors":["Shaaban KA","Damodaran C","Rohr J","Stamatkin C"],"additional_accession":[]},"is_claimable":false,"name":"11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain.","description":"Four new angucyclin(on)es, 11-deoxylandomycinone (1) and landomycins X-Z (2-4) were isolated from the crude extract of Streptomyces cyanogenus K62 mutant strain, along with the recently reported landomycins S, T and V (5-7) and five other known compounds. The structures of the new compounds 1-4 were elucidated by 1D and 2D NMR studies along with HR-MS analyses. Unique about the structures is that the fourth sugar moiety (sugar D) in landomycins X-Z (2-4) was β-D-amicetose instead of β-D-olivose, usually found in this position. The new angucyclin(on)es were biologically evaluated in comparison with previously known congeners against a small panel of MCF-7 (estrogen responsive) and MDA 231 (estrogen refractory) breast cancer cell lines. 11-deoxylandomycinone (IC(50) 2.1 ± 0.3 and 1.2 ± 0.4 μ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan","modification":"2025-04-04T19:42:55.884Z","creation":"2019-03-27T00:38:31Z"},"accession":"S-EPMC3030652","cross_references":{"pubmed":["20978514"],"doi":["10.1038/ja.2010.121"]}}