biostudies-literatureYoung KCNHLBI NIH HHS1678-85https://www.ebi.ac.uk/biostudies/studies/S-EPMC3033607biostudies-literatureUnknown75(19)<h4>Objective</h4>Multimodal CT, including noncontrast CT (NCCT), CT with contrast, CT angiography (CTA), and perfusion CT (CTP), is increasingly used in acute stroke patients to identify candidates for endovascular therapy. Our goal is to explore the cost-effectiveness of multimodal CT as a diagnostic test.<h4>Methods</h4>A Markov model compared multimodal CT to NCCT in a hypothetical cohort of nonhemorrhagic stroke patients presenting within 3 hours of symptom onset who were potential IV tPA candidates. Patients who failed to improve after IV tPA or in whom IV tPA was contraindicated were candidates for endovascular therapy. Direct costs (2008 USD), outcomes, and probabilities were obtained from the literature.<h4>Results</h4>For the 3-month time horizon, multimodal CT had lower costs (-NeurologyCost-effectiveness of multimodal CT for evaluating acute stroke.PMC3033607R01HL080107Young KCBenesch CGJahromi BSfalseCost-effectiveness of multimodal CT for evaluating acute stroke.<h4>Objective</h4>Multimodal CT, including noncontrast CT (NCCT), CT with contrast, CT angiography (CTA), and perfusion CT (CTP), is increasingly used in acute stroke patients to identify candidates for endovascular therapy. Our goal is to explore the cost-effectiveness of multimodal CT as a diagnostic test.<h4>Methods</h4>A Markov model compared multimodal CT to NCCT in a hypothetical cohort of nonhemorrhagic stroke patients presenting within 3 hours of symptom onset who were potential IV tPA candidates. Patients who failed to improve after IV tPA or in whom IV tPA was contraindicated were candidates for endovascular therapy. Direct costs (2008 USD), outcomes, and probabilities were obtained from the literature.<h4>Results</h4>For the 3-month time horizon, multimodal CT had lower costs (-2010-01-01T00:00:00Z2010 Nov2025-04-20T01:57:46.713Z2019-03-27T00:38:41ZS-EPMC30336072092678610.1212/wnl.0b013e3181fc283810.1212/WNL.0b013e3181fc2838