{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(3)"],"submitter":["Iwasawa R"],"pubmed_abstract":["The mitochondria and the endoplasmic reticulum (ER) are two organelles that critically contribute to apoptosis induction. While it is established that they communicate, how cell death signals are transmitted from the mitochondria to the ER is unknown. Here, we show that the mitochondrial fission protein Fission 1 homologue (Fis1) conveys an apoptosis signal from the mitochondria to the ER by interacting with Bap31 at the ER and facilitating its cleavage into the pro-apoptotic p20Bap31. Exogenous apoptosis inducers likewise use this signalling route and induce the procession of Bap31. Moreover, we show that the recruitment of procaspase-8 to the Fis1-Bap31 platform is an early event during apoptosis induction. The association of procaspase-8 with the Fis1-Bap31 complex is dependent on the v"],"journal":["The EMBO journal"],"pagination":["556-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3034017"],"repository":["biostudies-literature"],"pubmed_title":["Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction."],"pmcid":["PMC3034017"],"pubmed_authors":["Mahul-Mellier AL","Datler C","Iwasawa R","Grimm S","Pazarentzos E"],"additional_accession":[]},"is_claimable":false,"name":"Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.","description":"The mitochondria and the endoplasmic reticulum (ER) are two organelles that critically contribute to apoptosis induction. While it is established that they communicate, how cell death signals are transmitted from the mitochondria to the ER is unknown. Here, we show that the mitochondrial fission protein Fission 1 homologue (Fis1) conveys an apoptosis signal from the mitochondria to the ER by interacting with Bap31 at the ER and facilitating its cleavage into the pro-apoptotic p20Bap31. Exogenous apoptosis inducers likewise use this signalling route and induce the procession of Bap31. Moreover, we show that the recruitment of procaspase-8 to the Fis1-Bap31 platform is an early event during apoptosis induction. The association of procaspase-8 with the Fis1-Bap31 complex is dependent on the v","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Feb","modification":"2025-04-19T12:55:45.273Z","creation":"2019-03-27T00:38:43Z"},"accession":"S-EPMC3034017","cross_references":{"pubmed":["21183955"],"doi":["10.1038/emboj.2010.346"]}}