biostudies-literatureKim JHIntramural NIH HHSNIGMS NIH HHS638-51https://www.ebi.ac.uk/biostudies/studies/S-EPMC3034128biostudies-literatureUnknown54(7)<h4>Objectives</h4>We developed and tested a novel transcatheter circumferential annuloplasty technique to reduce mitral regurgitation in porcine ischemic cardiomyopathy.<h4>Background</h4>Catheter-based annuloplasty for secondary mitral regurgitation exploits the proximity of the coronary sinus to the mitral annulus, but is limited by anatomic variants and coronary artery entrapment.<h4>Methods</h4>The procedure, "cerclage annuloplasty," is guided by magnetic resonance imaging (MRI) roadmaps fused with live X-ray. A coronary sinus guidewire traverses a short segment of the basal septal myocardium to re-enter the right heart where it is exchanged for a suture. Tension is applied interactively during imaging and secured with a locking device.<h4>Results</h4>We found 2 feasible suture pathwaJournal of the American College of CardiologyMitral cerclage annuloplasty, a novel transcatheter treatment for secondary mitral valve regurgitation: initial results in swine.PMC3034128Z01 HL005062-05T32 GM008169Sampath SOzturk CSonmez MWright VJBerry CSchenke WHRaman VKKim AHFaranesh AZKocaturk OLederman RJSaikus CEMcVeigh ERKim JHDerbyshire JAfalseMitral cerclage annuloplasty, a novel transcatheter treatment for secondary mitral valve regurgitation: initial results in swine.<h4>Objectives</h4>We developed and tested a novel transcatheter circumferential annuloplasty technique to reduce mitral regurgitation in porcine ischemic cardiomyopathy.<h4>Background</h4>Catheter-based annuloplasty for secondary mitral regurgitation exploits the proximity of the coronary sinus to the mitral annulus, but is limited by anatomic variants and coronary artery entrapment.<h4>Methods</h4>The procedure, "cerclage annuloplasty," is guided by magnetic resonance imaging (MRI) roadmaps fused with live X-ray. A coronary sinus guidewire traverses a short segment of the basal septal myocardium to re-enter the right heart where it is exchanged for a suture. Tension is applied interactively during imaging and secured with a locking device.<h4>Results</h4>We found 2 feasible suture pathwa2009-01-01T00:00:00Z2009 Aug2025-04-22T05:06:03.339Z2019-03-27T00:38:43ZS-EPMC30341281966069610.1016/j.jacc.2009.03.071