{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gorman KF"],"funding":["NIAMS NIH HHS"],"pagination":["16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3039624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["<h4>Background</h4>Understanding the genetic basis of heritable spinal curvature would benefit medicine and aquaculture. Heritable spinal curvature among otherwise healthy children (i.e. Idiopathic Scoliosis and Scheuermann kyphosis) accounts for more than 80% of all spinal curvatures and imposes a substantial healthcare cost through bracing, hospitalizations, surgery, and chronic back pain. In aquaculture, the prevalence of heritable spinal curvature can reach as high as 80% of a stock, and thus imposes a substantial cost through production losses. The genetic basis of heritable spinal curvature is unknown and so the objective of this work is to identify quantitative trait loci (QTL) affecting heritable spinal curvature in the curveback guppy. Prior work with curveback has demonstrated ph"],"journal":["BMC genetics"],"pubmed_title":["A major QTL controls susceptibility to spinal curvature in the curveback guppy."],"pmcid":["PMC3039624"],"funding_grant_id":["1R21AR053730-01A2"],"pubmed_authors":["Breden F","Parent J","Weigel D","Gorman KF","Ahmadi R","Dreyer C","Christians JK"],"additional_accession":[]},"is_claimable":false,"name":"A major QTL controls susceptibility to spinal curvature in the curveback guppy.","description":"<h4>Background</h4>Understanding the genetic basis of heritable spinal curvature would benefit medicine and aquaculture. Heritable spinal curvature among otherwise healthy children (i.e. Idiopathic Scoliosis and Scheuermann kyphosis) accounts for more than 80% of all spinal curvatures and imposes a substantial healthcare cost through bracing, hospitalizations, surgery, and chronic back pain. In aquaculture, the prevalence of heritable spinal curvature can reach as high as 80% of a stock, and thus imposes a substantial cost through production losses. The genetic basis of heritable spinal curvature is unknown and so the objective of this work is to identify quantitative trait loci (QTL) affecting heritable spinal curvature in the curveback guppy. Prior work with curveback has demonstrated ph","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan","modification":"2025-05-29T20:56:05.125Z","creation":"2025-05-29T20:56:05.125Z"},"accession":"S-EPMC3039624","cross_references":{"pubmed":["21269476"],"doi":["10.1186/1471-2156-12-16"]}}