{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rumpf S"],"funding":["Howard Hughes Medical Institute","NINDS NIH HHS"],"pagination":["1153-60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3042870"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["138(6)"],"pubmed_abstract":["The regulated degeneration of axons or dendrites (pruning) and neuronal apoptosis are widely used during development to determine the specificity of neuronal connections. Pruning and apoptosis often share similar mechanisms; for example, developmental dendrite pruning of Drosophila class IV dendritic arborization (da) neurons is induced by local caspase activation triggered by ubiquitin-mediated degradation of the caspase inhibitor DIAP1. Here, we examined the function of Valosin-containing protein (VCP), a ubiquitin-selective AAA chaperone involved in endoplasmic reticulum-associated degradation, autophagy and neurodegenerative disease, in Drosophila da neurons. Strong VCP inhibition is cell lethal, but milder inhibition interferes with dendrite pruning and developmental apoptosis. These "],"journal":["Development (Cambridge, England)"],"pubmed_title":["Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1."],"pmcid":["PMC3042870"],"funding_grant_id":["R 37NS040929"],"pubmed_authors":["Jan LY","Rumpf S","Lee SB","Jan YN"],"additional_accession":[]},"is_claimable":false,"name":"Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.","description":"The regulated degeneration of axons or dendrites (pruning) and neuronal apoptosis are widely used during development to determine the specificity of neuronal connections. Pruning and apoptosis often share similar mechanisms; for example, developmental dendrite pruning of Drosophila class IV dendritic arborization (da) neurons is induced by local caspase activation triggered by ubiquitin-mediated degradation of the caspase inhibitor DIAP1. Here, we examined the function of Valosin-containing protein (VCP), a ubiquitin-selective AAA chaperone involved in endoplasmic reticulum-associated degradation, autophagy and neurodegenerative disease, in Drosophila da neurons. Strong VCP inhibition is cell lethal, but milder inhibition interferes with dendrite pruning and developmental apoptosis. These ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-19T21:12:56.626Z","creation":"2019-03-27T00:39:08Z"},"accession":"S-EPMC3042870","cross_references":{"pubmed":["21343367"],"doi":["10.1242/dev.062703"]}}