{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rey G"],"funding":["Swiss National Science Foundation"],"pagination":["e1000595"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3043000"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(2)"],"pubmed_abstract":["The mammalian circadian clock uses interlocked negative feedback loops in which the heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator. While there is prominent control of liver functions by the circadian clock, the detailed links between circadian regulators and downstream targets are poorly known. Using chromatin immunoprecipitation combined with deep sequencing we obtained a time-resolved and genome-wide map of BMAL1 binding in mouse liver, which allowed us to identify over 2,000 binding sites, with peak binding narrowly centered around Zeitgeber time 6. Annotation of BMAL1 targets confirms carbohydrate and lipid metabolism as the major output of the circadian clock in mouse liver. Moreover, transcription regulators are largely overrepresented, s"],"journal":["PLoS biology"],"pubmed_title":["Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver."],"pmcid":["PMC3043000"],"funding_grant_id":["113617"],"pubmed_authors":["Rougemont J","Cesbron F","Reinke H","Brunner M","Naef F","Rey G"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver.","description":"The mammalian circadian clock uses interlocked negative feedback loops in which the heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator. While there is prominent control of liver functions by the circadian clock, the detailed links between circadian regulators and downstream targets are poorly known. Using chromatin immunoprecipitation combined with deep sequencing we obtained a time-resolved and genome-wide map of BMAL1 binding in mouse liver, which allowed us to identify over 2,000 binding sites, with peak binding narrowly centered around Zeitgeber time 6. Annotation of BMAL1 targets confirms carbohydrate and lipid metabolism as the major output of the circadian clock in mouse liver. Moreover, transcription regulators are largely overrepresented, s","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Feb","modification":"2026-05-02T14:46:33.902Z","creation":"2026-04-07T18:08:03.905Z"},"accession":"S-EPMC3043000","cross_references":{"pubmed":["21364973"],"doi":["10.1371/journal.pbio.1000595"]}}