{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ristic N"],"funding":["NIDA NIH HHS"],"pagination":["e17485"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3046974"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(3)"],"pubmed_abstract":["<h4>Background</h4>HIV-1 subtype B and subtype F are prevalent in the AIDS epidemic of Brazil. Recombinations between these subtypes have generated at least four BF circulating recombinant forms (CRFs). CRF28_BF and CRF29_BF are among the first two BF recombinants being identified in Brazil and they contributed significantly to the epidemic. However, the evolution and demographic histories of the CRFs are unclear.<h4>Methodology/principal findings</h4>A collection of gag and pol sequences sampled within Brazil was screened for CRF28_BF-like and CRF29_BF-like recombination patterns. A Bayesian coalescent framework was employed to delineate the phylogenetic, divergence time and population dynamics of the virus having CRF28_BF-like and CRF29_BF-like genotype. These recombinants were phylogene"],"journal":["PloS one"],"pubmed_title":["Analysis of the origin and evolutionary history of HIV-1 CRF28_BF and CRF29_BF reveals a decreasing prevalence in the AIDS epidemic of Brazil."],"pmcid":["PMC3046974"],"funding_grant_id":["R00 DA026293","DA026293","K99 DA026293"],"pubmed_authors":["Diaz RS","Janini LM","Zukurov J","Chin MP","Alkmim W","Ristic N"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of the origin and evolutionary history of HIV-1 CRF28_BF and CRF29_BF reveals a decreasing prevalence in the AIDS epidemic of Brazil.","description":"<h4>Background</h4>HIV-1 subtype B and subtype F are prevalent in the AIDS epidemic of Brazil. Recombinations between these subtypes have generated at least four BF circulating recombinant forms (CRFs). CRF28_BF and CRF29_BF are among the first two BF recombinants being identified in Brazil and they contributed significantly to the epidemic. However, the evolution and demographic histories of the CRFs are unclear.<h4>Methodology/principal findings</h4>A collection of gag and pol sequences sampled within Brazil was screened for CRF28_BF-like and CRF29_BF-like recombination patterns. A Bayesian coalescent framework was employed to delineate the phylogenetic, divergence time and population dynamics of the virus having CRF28_BF-like and CRF29_BF-like genotype. These recombinants were phylogene","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2026-04-07T22:07:10.824Z","creation":"2019-03-26T23:12:12Z"},"accession":"S-EPMC3046974","cross_references":{"pubmed":["21390250"],"doi":["10.1371/journal.pone.0017485"]}}