{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["286(10)"],"submitter":["Freire T"],"pubmed_abstract":["The Tn antigen (α-GalNAc-O-Ser/Thr) is one of the most specific human cancer-associated structures. This antigen, together with mucins, the major carriers of O-glycosylated tumor antigens in adenocarcinomas, are being evaluated as anti-cancer immunotherapeutic targets. In particular, the MUC6 protein, which is normally expressed only in gastric tissues, has been detected in intestinal, pulmonary, colorectal, and breast carcinomas. To develop anti-cancer vaccines based on the Tn antigen, we produced MUC6 proteins with different Tn density by using mixtures of recombinant ppGalNAc-T1, -T2, and -T7. The obtained glycoproteins were characterized and analyzed for their immunological properties, as compared with the non-glycosylated MUC6. We show that these various MUC6:Tn glycoproteins were wel"],"journal":["The Journal of biological chemistry"],"pagination":["7797-7811"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3048667"],"repository":["biostudies-literature"],"pubmed_title":["Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses."],"pmcid":["PMC3048667"],"pubmed_authors":["Bay S","Lo-Man R","Leclerc C","Freire T"],"additional_accession":[]},"is_claimable":false,"name":"Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses.","description":"The Tn antigen (α-GalNAc-O-Ser/Thr) is one of the most specific human cancer-associated structures. This antigen, together with mucins, the major carriers of O-glycosylated tumor antigens in adenocarcinomas, are being evaluated as anti-cancer immunotherapeutic targets. In particular, the MUC6 protein, which is normally expressed only in gastric tissues, has been detected in intestinal, pulmonary, colorectal, and breast carcinomas. To develop anti-cancer vaccines based on the Tn antigen, we produced MUC6 proteins with different Tn density by using mixtures of recombinant ppGalNAc-T1, -T2, and -T7. The obtained glycoproteins were characterized and analyzed for their immunological properties, as compared with the non-glycosylated MUC6. We show that these various MUC6:Tn glycoproteins were wel","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-04T20:12:56.909Z","creation":"2019-03-27T00:39:22Z"},"accession":"S-EPMC3048667","cross_references":{"pubmed":["21193402"],"doi":["10.1074/jbc.M110.209742","10.1074/jbc.m110.209742"]}}