{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Myoung J"],"funding":["NIDCR NIH HHS","Howard Hughes Medical Institute"],"pagination":["1130-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3049404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(3)"],"pubmed_abstract":["Kaposi sarcoma-associated herpesvirus (KSHV) is a B-lymphotropic virus whose primary site of replication is the oropharynx. KSHV can infect both T and B cells from primary tonsillar explant cultures. However, T cells do not support lytic replication, while B cells spontaneously produce substantial amounts of infectious virus. Here, we provide evidence for a mechanism by which activated T cells may promote or stabilize latency of KSHV infection in B cells. When mixed cultures of B cells and activated T cells were exposed to KSHV, little spontaneous virus production was observed. Removing T cells from the mix or treating the mixed culture with immune suppressants enhanced virus production. Adding back activated T cells to purified infected B cells efficiently suppressed KSHV production, prim"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells."],"pmcid":["PMC3049404"],"funding_grant_id":["P01 DE019085","P01DE019085"],"pubmed_authors":["Ganem D","Myoung J"],"additional_accession":[]},"is_claimable":false,"name":"Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells.","description":"Kaposi sarcoma-associated herpesvirus (KSHV) is a B-lymphotropic virus whose primary site of replication is the oropharynx. KSHV can infect both T and B cells from primary tonsillar explant cultures. However, T cells do not support lytic replication, while B cells spontaneously produce substantial amounts of infectious virus. Here, we provide evidence for a mechanism by which activated T cells may promote or stabilize latency of KSHV infection in B cells. When mixed cultures of B cells and activated T cells were exposed to KSHV, little spontaneous virus production was observed. Removing T cells from the mix or treating the mixed culture with immune suppressants enhanced virus production. Adding back activated T cells to purified infected B cells efficiently suppressed KSHV production, prim","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-07T00:15:14.641Z","creation":"2019-03-27T00:39:24Z"},"accession":"S-EPMC3049404","cross_references":{"pubmed":["21339648"],"doi":["10.1172/JCI43755","10.1172/jci43755"]}}