{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Narayanan D"],"funding":["NHLBI NIH HHS"],"pagination":["631-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3050675"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(5)"],"pubmed_abstract":["<h4>Rationale</h4>Physiological functions of mitochondria in contractile arterial myocytes are poorly understood. Mitochondria can uptake calcium (Ca(2+)), but intracellular Ca(2+) signals that regulate mitochondrial Ca(2+) concentration ([Ca(2+)](mito)) and physiological functions of changes in [Ca(2+)](mito) in arterial myocytes are unclear.<h4>Objective</h4>To identify Ca(2+) signals that regulate [Ca(2+)](mito), examine the significance of changes in [Ca(2+)](mito), and test the hypothesis that [Ca(2+)](mito) controls functional ion channel transcription in myocytes of resistance-size cerebral arteries.<h4>Methods and results</h4>Endothelin (ET)-1 activated Ca(2+) waves and elevated global Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activation."],"journal":["Circulation research"],"pubmed_title":["Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries."],"pmcid":["PMC3050675"],"funding_grant_id":["R01 HL067061-08","R01 HL077678-04","R01 HL077678-03","R01 HL067061-09","HL77678","R01 HL094378-01A1","R01 HL067061-07","R01 HL077678","R01 HL067061","HL67061","R01 HL094378","R01 HL077678-02","HL094378","R01 HL094378-02"],"pubmed_authors":["Narayanan D","Xi Q","Jaggar JH","Pfeffer LM"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries.","description":"<h4>Rationale</h4>Physiological functions of mitochondria in contractile arterial myocytes are poorly understood. Mitochondria can uptake calcium (Ca(2+)), but intracellular Ca(2+) signals that regulate mitochondrial Ca(2+) concentration ([Ca(2+)](mito)) and physiological functions of changes in [Ca(2+)](mito) in arterial myocytes are unclear.<h4>Objective</h4>To identify Ca(2+) signals that regulate [Ca(2+)](mito), examine the significance of changes in [Ca(2+)](mito), and test the hypothesis that [Ca(2+)](mito) controls functional ion channel transcription in myocytes of resistance-size cerebral arteries.<h4>Methods and results</h4>Endothelin (ET)-1 activated Ca(2+) waves and elevated global Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activation.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Sep","modification":"2025-04-20T03:59:33.997Z","creation":"2019-03-26T23:49:21Z"},"accession":"S-EPMC3050675","cross_references":{"pubmed":["20616314"],"doi":["10.1161/circresaha.110.224345","10.1161/CIRCRESAHA.110.224345"]}}