biostudies-literatureNarayanan DNHLBI NIH HHS631-41https://www.ebi.ac.uk/biostudies/studies/S-EPMC3050675biostudies-literatureUnknown107(5)<h4>Rationale</h4>Physiological functions of mitochondria in contractile arterial myocytes are poorly understood. Mitochondria can uptake calcium (Ca(2+)), but intracellular Ca(2+) signals that regulate mitochondrial Ca(2+) concentration ([Ca(2+)](mito)) and physiological functions of changes in [Ca(2+)](mito) in arterial myocytes are unclear.<h4>Objective</h4>To identify Ca(2+) signals that regulate [Ca(2+)](mito), examine the significance of changes in [Ca(2+)](mito), and test the hypothesis that [Ca(2+)](mito) controls functional ion channel transcription in myocytes of resistance-size cerebral arteries.<h4>Methods and results</h4>Endothelin (ET)-1 activated Ca(2+) waves and elevated global Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activation.Circulation researchMitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries.PMC3050675R01 HL067061-08R01 HL077678-04R01 HL077678-03R01 HL067061-09HL77678R01 HL094378-01A1R01 HL067061-07R01 HL077678R01 HL067061HL67061R01 HL094378R01 HL077678-02HL094378R01 HL094378-02Narayanan DXi QJaggar JHPfeffer LMfalseMitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries.<h4>Rationale</h4>Physiological functions of mitochondria in contractile arterial myocytes are poorly understood. Mitochondria can uptake calcium (Ca(2+)), but intracellular Ca(2+) signals that regulate mitochondrial Ca(2+) concentration ([Ca(2+)](mito)) and physiological functions of changes in [Ca(2+)](mito) in arterial myocytes are unclear.<h4>Objective</h4>To identify Ca(2+) signals that regulate [Ca(2+)](mito), examine the significance of changes in [Ca(2+)](mito), and test the hypothesis that [Ca(2+)](mito) controls functional ion channel transcription in myocytes of resistance-size cerebral arteries.<h4>Methods and results</h4>Endothelin (ET)-1 activated Ca(2+) waves and elevated global Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activation.2010-01-01T00:00:00Z2010 Sep2025-04-20T03:59:33.997Z2019-03-26T23:49:21ZS-EPMC30506752061631410.1161/circresaha.110.22434510.1161/CIRCRESAHA.110.224345