biostudies-literatureFeng LNHLBI NIH HHS206-16https://www.ebi.ac.uk/biostudies/studies/S-EPMC3050864biostudies-literatureUnknown13(3)Extracellular adenosine triphosphate (ATP) is known to boost immune responses in the tumor microenvironment but might also contribute directly to cancer cell death. CD39/ENTPD1 is the dominant ectonucleotidase expressed by endothelial cells and regulatory T cells and catalyzes the sequential hydrolysis of ATP to AMP that is further degraded to adenosine by CD73/ecto-5'-nucleotidase. We have previously shown that deletion of Cd39 results in decreased growth of transplanted tumors in mice, as a result of both defective angiogenesis and heightened innate immune responses (secondary to loss of adenosinergic immune suppression). Whether alterations in local extracellular ATP and adenosine levels as a result of CD39 bioactivity directly affect tumor growth and cytotoxicity has not been investigaNeoplasia (New York, N.Y.)Vascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate.PMC3050864P01-HL076540R01 HL063972R01 HL063972-08R01-HL094400R01 HL057307-08R01 HL057307R01 HL094400-02P01 HL076540R01 HL094400Feng LBian SCsizmadia EHan LWang XSun XMurakami TWu YRobson SCfalseVascular CD39/ENTPD1 directly promotes tumor cell growth by scavenging extracellular adenosine triphosphate.Extracellular adenosine triphosphate (ATP) is known to boost immune responses in the tumor microenvironment but might also contribute directly to cancer cell death. CD39/ENTPD1 is the dominant ectonucleotidase expressed by endothelial cells and regulatory T cells and catalyzes the sequential hydrolysis of ATP to AMP that is further degraded to adenosine by CD73/ecto-5'-nucleotidase. We have previously shown that deletion of Cd39 results in decreased growth of transplanted tumors in mice, as a result of both defective angiogenesis and heightened innate immune responses (secondary to loss of adenosinergic immune suppression). Whether alterations in local extracellular ATP and adenosine levels as a result of CD39 bioactivity directly affect tumor growth and cytotoxicity has not been investiga2011-01-01T00:00:00Z2011 Mar2025-04-20T04:00:09.02Z2019-03-27T00:39:28ZS-EPMC30508642139018410.1593/neo.101332