{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ou HD"],"funding":["NCI NIH HHS"],"pagination":["48-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3053133"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["One of the greatest challenges in biomedicine is to define the critical targets and network interactions that are subverted to elicit growth deregulation in human cells. Understanding and developing rational treatments for cancer requires a definition of the key molecular targets and how they interact to elicit the complex growth deregulation phenotype. Viral proteins provide discerning and powerful probes to understand both how cells work and how they can be manipulated using a minimal number of components. The small DNA viruses have evolved to target inherent weaknesses in cellular protein interaction networks to hijack the cellular DNA and protein replication machinery. In the battle to escape the inevitability of senescence and programmed cell death, cancers have converged on similar m"],"journal":["Wiley interdisciplinary reviews. Systems biology and medicine"],"pubmed_title":["The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication."],"pmcid":["PMC3053133"],"funding_grant_id":["T32 CA009370","R01 CA137094-02","R01 CA137094-01","T32 CA009370-27","R01CA137094","R01 CA137094"],"pubmed_authors":["O'Shea CC","Ou HD","May AP"],"additional_accession":[]},"is_claimable":false,"name":"The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication.","description":"One of the greatest challenges in biomedicine is to define the critical targets and network interactions that are subverted to elicit growth deregulation in human cells. Understanding and developing rational treatments for cancer requires a definition of the key molecular targets and how they interact to elicit the complex growth deregulation phenotype. Viral proteins provide discerning and powerful probes to understand both how cells work and how they can be manipulated using a minimal number of components. The small DNA viruses have evolved to target inherent weaknesses in cellular protein interaction networks to hijack the cellular DNA and protein replication machinery. In the battle to escape the inevitability of senescence and programmed cell death, cancers have converged on similar m","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Jan-Feb","modification":"2025-04-25T20:36:20.422Z","creation":"2020-11-07T09:52:30Z"},"accession":"S-EPMC3053133","cross_references":{"pubmed":["21061422"],"doi":["10.1002/wsbm.88"]}}