{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fu Y"],"funding":["NHLBI NIH HHS"],"pagination":["410-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3053136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(4)"],"pubmed_abstract":["<h4>Rationale</h4>Endothelial cells (ECs) have distinct mechanotransduction mechanisms responding to laminar versus disturbed flow patterns. Endothelial dysfunction, affected by imposed flow, is one of the earliest events leading to atherogenesis. The involvement of γ/δ T lymphocytes in endothelial dysfunction under flow is largely unknown.<h4>Objective</h4>To investigate whether shear stress regulates membrane translocation of ATP synthase β chain (ATPSβ) in ECs, leading to the increased γ/δ T-lymphocyte adhesion and the related functions.<h4>Method and results</h4>We applied different flow patterns to cultured ECs. Laminar flow decreased the level of membrane-bound ATPSβ (ecto-ATPSβ) and depleted membrane cholesterol, whereas oscillatory flow increased the level of ecto-ATPSβ and membran"],"journal":["Circulation research"],"pubmed_title":["A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain."],"pmcid":["PMC3053136"],"funding_grant_id":["HL89940","HL105318","R01 HL105318","R01 HL089940-02","R01 HL089940","R01 HL105318-01"],"pubmed_authors":["Fu C","Li C","Zhu Y","Shyy JY","Fu Y","Gu M","Wang X","Hou Y","Kong W"],"additional_accession":[]},"is_claimable":false,"name":"A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain.","description":"<h4>Rationale</h4>Endothelial cells (ECs) have distinct mechanotransduction mechanisms responding to laminar versus disturbed flow patterns. Endothelial dysfunction, affected by imposed flow, is one of the earliest events leading to atherogenesis. The involvement of γ/δ T lymphocytes in endothelial dysfunction under flow is largely unknown.<h4>Objective</h4>To investigate whether shear stress regulates membrane translocation of ATP synthase β chain (ATPSβ) in ECs, leading to the increased γ/δ T-lymphocyte adhesion and the related functions.<h4>Method and results</h4>We applied different flow patterns to cultured ECs. Laminar flow decreased the level of membrane-bound ATPSβ (ecto-ATPSβ) and depleted membrane cholesterol, whereas oscillatory flow increased the level of ecto-ATPSβ and membran","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Feb","modification":"2025-04-22T05:07:12.374Z","creation":"2019-03-26T23:49:21Z"},"accession":"S-EPMC3053136","cross_references":{"pubmed":["21193741"],"doi":["10.1161/CIRCRESAHA.110.230151","10.1161/circresaha.110.230151"]}}