{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(3)"],"submitter":["Mendez V"],"pubmed_abstract":["<h4>Background</h4>Genome characterization of the model PCB-degrading bacterium Burkholderia xenovorans LB400 revealed the presence of eleven central pathways for aromatic compounds degradation, among them, the homogentisate and the homoprotocatechuate pathways. However, the functionality of these central pathways in strain LB400 has not been assessed and related peripheral pathways has not been described.<h4>Methodology/principal findings</h4>The aims of this study were to determine the functionality of the homogentisate and homoprotocatechuate central pathways in B. xenovorans LB400 and to establish their role in 3-hydroxyphenylacetate (3-HPA) and 4-hydroxyphenylacetate (4-HPA) catabolism. Strain LB400 was able to grow using 3-HPA and 4-HPA as sole carbon source. A genomic search in LB40"],"journal":["PloS one"],"pagination":["e17583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3053370"],"repository":["biostudies-literature"],"pubmed_title":["The homogentisate and homoprotocatechuate central pathways are involved in 3- and 4-hydroxyphenylacetate degradation by Burkholderia xenovorans LB400."],"pmcid":["PMC3053370"],"pubmed_authors":["Agullo L","Seeger M","Gonzalez M","Mendez V"],"additional_accession":[]},"is_claimable":false,"name":"The homogentisate and homoprotocatechuate central pathways are involved in 3- and 4-hydroxyphenylacetate degradation by Burkholderia xenovorans LB400.","description":"<h4>Background</h4>Genome characterization of the model PCB-degrading bacterium Burkholderia xenovorans LB400 revealed the presence of eleven central pathways for aromatic compounds degradation, among them, the homogentisate and the homoprotocatechuate pathways. However, the functionality of these central pathways in strain LB400 has not been assessed and related peripheral pathways has not been described.<h4>Methodology/principal findings</h4>The aims of this study were to determine the functionality of the homogentisate and homoprotocatechuate central pathways in B. xenovorans LB400 and to establish their role in 3-hydroxyphenylacetate (3-HPA) and 4-hydroxyphenylacetate (4-HPA) catabolism. Strain LB400 was able to grow using 3-HPA and 4-HPA as sole carbon source. A genomic search in LB40","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-25T18:19:55.77Z","creation":"2019-06-06T22:42:42Z"},"accession":"S-EPMC3053370","cross_references":{"pubmed":["21423751"],"doi":["10.1371/journal.pone.0017583"]}}