{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rolland M"],"funding":["NIAID NIH HHS"],"pagination":["366-71"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3053571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(3)"],"pubmed_abstract":["We analyzed HIV-1 genome sequences from 68 newly infected volunteers in the STEP HIV-1 vaccine trial. To determine whether the vaccine exerted selective T cell pressure on breakthrough viruses, we identified potential T cell epitopes in the founder sequences and compared them to epitopes in the vaccine. We found greater distances to the vaccine sequence for sequences from vaccine recipients than from placebo recipients. The most significant signature site distinguishing vaccine from placebo recipients was Gag amino acid 84, a site encompassed by several epitopes contained in the vaccine and restricted by human leukocyte antigen (HLA) alleles common in the study cohort. Moreover, the extended divergence was confined to the vaccine components of the virus (HIV-1 Gag, Pol and Nef) and not found in other HIV-1 proteins. These results represent what is to our knowledge the first evidence of selective pressure from vaccine-induced T cell responses on HIV-1 infection in humans."],"journal":["Nature medicine"],"pubmed_title":["Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial."],"pmcid":["PMC3053571"],"funding_grant_id":["P30 AI027757","U01 AI068618","R37 AI054165","U01 AI068618-06","AI41505"],"pubmed_authors":["Sorensen S","Rolland M","Robertson MN","Stoddard JN","Sanders-Buell E","Kim J","O'Sullivan A","Bradfield A","McCutchan FE","Tovanabutra S","Casimiro DR","Mullins JI","Nau M","Self SG","Wong K","Dubey S","Bose M","Raugi DN","Deng W","Shiver J","McElrath MJ","Zhao H","Hural J","Heath L","Gilbert PB","Duerr A","Corey L","Li F","Maust BS","Frahm N","Magaret CA","deCamp AC","Buchbinder S","Crossler J","Michael NL","Jones T"],"additional_accession":[]},"is_claimable":false,"name":"Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial.","description":"We analyzed HIV-1 genome sequences from 68 newly infected volunteers in the STEP HIV-1 vaccine trial. To determine whether the vaccine exerted selective T cell pressure on breakthrough viruses, we identified potential T cell epitopes in the founder sequences and compared them to epitopes in the vaccine. We found greater distances to the vaccine sequence for sequences from vaccine recipients than from placebo recipients. The most significant signature site distinguishing vaccine from placebo recipients was Gag amino acid 84, a site encompassed by several epitopes contained in the vaccine and restricted by human leukocyte antigen (HLA) alleles common in the study cohort. Moreover, the extended divergence was confined to the vaccine components of the virus (HIV-1 Gag, Pol and Nef) and not found in other HIV-1 proteins. These results represent what is to our knowledge the first evidence of selective pressure from vaccine-induced T cell responses on HIV-1 infection in humans.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-05-29T21:10:21.776Z","creation":"2019-03-27T00:39:32Z"},"accession":"S-EPMC3053571","cross_references":{"pubmed":["21358627"],"doi":["10.1038/nm.2316"]}}