{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo G"],"funding":["NCRR NIH HHS","NIGMS NIH HHS","CIHR"],"pagination":["8759-70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3059008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["286(11)"],"pubmed_abstract":["Regulated mRNA decay is essential for eukaryotic survival but the mechanisms for regulating global decay and coordinating it with growth, nutrient, and environmental cues are not known. Here we show that a signal transduction pathway containing the Pkh1/Pkh2 protein kinases and one of their effector kinases, Pkc1, is required for and regulates global mRNA decay at the deadenylation step in Saccharomyces cerevisiae. Additionally, many stresses disrupt protein synthesis and release mRNAs from polysomes for incorporation into P-bodies for degradation or storage. We find that the Pkh1/2-Pkc1 pathway is also required for stress-induced P-body assembly. Control of mRNA decay and P-body assembly by the Pkh-Pkc1 pathway only occurs in nutrient-poor medium, suggesting a novel role for these process"],"journal":["The Journal of biological chemistry"],"pubmed_title":["Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast."],"pmcid":["PMC3059008"],"funding_grant_id":["GM41302","P20-RR020171","P20 RR020171","R01 GM041302"],"pubmed_authors":["Costanzo M","Dickson RC","Luo G","Boone C"],"additional_accession":[]},"is_claimable":false,"name":"Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast.","description":"Regulated mRNA decay is essential for eukaryotic survival but the mechanisms for regulating global decay and coordinating it with growth, nutrient, and environmental cues are not known. Here we show that a signal transduction pathway containing the Pkh1/Pkh2 protein kinases and one of their effector kinases, Pkc1, is required for and regulates global mRNA decay at the deadenylation step in Saccharomyces cerevisiae. Additionally, many stresses disrupt protein synthesis and release mRNAs from polysomes for incorporation into P-bodies for degradation or storage. We find that the Pkh1/2-Pkc1 pathway is also required for stress-induced P-body assembly. Control of mRNA decay and P-body assembly by the Pkh-Pkc1 pathway only occurs in nutrient-poor medium, suggesting a novel role for these process","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-19T12:55:31.433Z","creation":"2019-03-27T00:39:46Z"},"accession":"S-EPMC3059008","cross_references":{"pubmed":["21163942"],"doi":["10.1074/jbc.M110.196030","10.1074/jbc.m110.196030"]}}