{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Caronia-Brown G"],"funding":["NIMH NIH HHS","PHS HHS"],"pagination":["748-55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3059882"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(4)"],"pubmed_abstract":["Cerebral cortical γ-aminobutyric acid (GABA)ergic interneurons originate from the basal forebrain and migrate into the cortex in 2 phases. First, interneurons cross the boundary between the developing striatum and the cortex to migrate tangentially through the cortical primordium. Second, interneurons migrate radially to their correct neocortical layer position. A previous study demonstrated that mice in which the cortical hem was genetically ablated displayed a massive reduction of Cajal-Retzius (C-R) cells in the neocortical marginal zone (MZ), thereby losing C-R cell-generated reelin in the MZ. Surprisingly, pyramidal cell migration and subsequent layering were almost normal. In contrast, we find that the timing of migration of cortical GABAergic interneurons is abnormal in hem-ablated "],"journal":["Cerebral cortex (New York, N.Y. : 1991)"],"pubmed_title":["Timing of cortical interneuron migration is influenced by the cortical hem."],"pmcid":["PMC3059882"],"funding_grant_id":["R37 MH059962","R37 H059962","R37 MH059962-12"],"pubmed_authors":["Grove EA","Caronia-Brown G"],"additional_accession":[]},"is_claimable":false,"name":"Timing of cortical interneuron migration is influenced by the cortical hem.","description":"Cerebral cortical γ-aminobutyric acid (GABA)ergic interneurons originate from the basal forebrain and migrate into the cortex in 2 phases. First, interneurons cross the boundary between the developing striatum and the cortex to migrate tangentially through the cortical primordium. Second, interneurons migrate radially to their correct neocortical layer position. A previous study demonstrated that mice in which the cortical hem was genetically ablated displayed a massive reduction of Cajal-Retzius (C-R) cells in the neocortical marginal zone (MZ), thereby losing C-R cell-generated reelin in the MZ. Surprisingly, pyramidal cell migration and subsequent layering were almost normal. In contrast, we find that the timing of migration of cortical GABAergic interneurons is abnormal in hem-ablated ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Apr","modification":"2025-04-19T21:40:30.43Z","creation":"2019-03-27T00:39:50Z"},"accession":"S-EPMC3059882","cross_references":{"pubmed":["20713502"],"doi":["10.1093/cercor/bhq142"]}}