{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Spannhoff A"],"funding":["NIEHS NIH HHS"],"pagination":["238-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3059907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly--the secretion produced by the hypopharyngeal and mandibular glands of worker bees--has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is "],"journal":["EMBO reports"],"pubmed_title":["Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees."],"pmcid":["PMC3059907"],"funding_grant_id":["ES007784","P30 ES007784"],"pubmed_authors":["Raynal NJ","Li J","Sbardella G","Spannhoff A","Su MB","Bedford MT","Kim YK","Gharibyan V","Zhou YY","Issa JP","Castellano S"],"additional_accession":[]},"is_claimable":false,"name":"Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.","description":"Worker and queen bees are genetically indistinguishable. However, queen bees are fertile, larger and have a longer lifespan than their female worker counterparts. Differential feeding of larvae with royal jelly controls this caste switching. There is emerging evidence that the queen-bee phenotype is driven by epigenetic mechanisms. In this study, we show that royal jelly--the secretion produced by the hypopharyngeal and mandibular glands of worker bees--has histone deacetylase inhibitor (HDACi) activity. A fatty acid, (E)-10-hydroxy-2-decenoic acid (10HDA), which accounts for up to 5% of royal jelly, harbours this HDACi activity. Furthermore, 10HDA can reactivate the expression of epigenetically silenced genes in mammalian cells. Thus, the epigenetic regulation of queen-bee development is ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-19T21:40:33.381Z","creation":"2019-03-27T00:39:50Z"},"accession":"S-EPMC3059907","cross_references":{"pubmed":["21331099"],"doi":["10.1038/embor.2011.9"]}}