{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Brideau NJ"],"pubmed_abstract":["<h4>Background</h4>Hybrid incompatibilities such as sterility and lethality are commonly modeled as being caused by interactions between two genes, each of which has diverged separately in one of the hybridizing lineages. The gene Lethal hybrid rescue (Lhr) encodes a rapidly evolving heterochromatin protein that causes lethality of hybrid males in crosses between Drosophila melanogaster females and D. simulans males. Previous genetic analyses showed that hybrid lethality is caused by D. simulans Lhr but not by D. melanogaster Lhr, confirming a critical prediction of asymmetry in the evolution of a hybrid incompatibility gene.<h4>Results</h4>Here we have examined the functional properties of Lhr orthologs from multiple Drosophila species, including interactions with other heterochromatin pr"],"journal":["BMC evolutionary biology"],"pagination":["57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3060119"],"repository":["biostudies-literature"],"pubmed_title":["Functional conservation of the Drosophila hybrid incompatibility gene Lhr."],"pmcid":["PMC3060119"],"pubmed_authors":["Barbash DA","Brideau NJ"],"additional_accession":[]},"is_claimable":false,"name":"Functional conservation of the Drosophila hybrid incompatibility gene Lhr.","description":"<h4>Background</h4>Hybrid incompatibilities such as sterility and lethality are commonly modeled as being caused by interactions between two genes, each of which has diverged separately in one of the hybridizing lineages. The gene Lethal hybrid rescue (Lhr) encodes a rapidly evolving heterochromatin protein that causes lethality of hybrid males in crosses between Drosophila melanogaster females and D. simulans males. Previous genetic analyses showed that hybrid lethality is caused by D. simulans Lhr but not by D. melanogaster Lhr, confirming a critical prediction of asymmetry in the evolution of a hybrid incompatibility gene.<h4>Results</h4>Here we have examined the functional properties of Lhr orthologs from multiple Drosophila species, including interactions with other heterochromatin pr","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-19T21:40:50.931Z","creation":"2019-03-27T00:39:51Z"},"accession":"S-EPMC3060119","cross_references":{"pubmed":["21366928"],"doi":["10.1186/1471-2148-11-57"]}}