{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sandling JK"],"funding":["NCRR NIH HHS","NIAMS NIH HHS"],"pagination":["479-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3060320"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(4)"],"pubmed_abstract":["Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease in which the type I interferon pathway has a crucial role. We have previously shown that three genes in this pathway, IRF5, TYK2 and STAT4, are strongly associated with risk for SLE. Here, we investigated 78 genes involved in the type I interferon pathway to identify additional SLE susceptibility loci. First, we genotyped 896 single-nucleotide polymorphisms in these 78 genes and 14 other candidate genes in 482 Swedish SLE patients and 536 controls. Genes with P<0.01 in the initial screen were then followed up in 344 additional Swedish patients and 1299 controls. SNPs in the IKBKE, TANK, STAT1, IL8 and TRAF6 genes gave nominal signals of association with SLE in this extended Swedish cohort. To replicate these findings we ex"],"journal":["European journal of human genetics : EJHG"],"pubmed_title":["A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE."],"pmcid":["PMC3060320"],"funding_grant_id":["R01 AR44804","K24 AR02175","M01 RR000079","K24 AR002175","5 M01 RR00079"],"pubmed_authors":["Criswell LA","Sandling JK","Wang C","Padyukov L","Nordmark G","Eloranta ML","Garnier S","Behrens TW","Malarstig A","Alm G","Svenungsson E","Truedsson L","Eriksson C","Ronnblom L","Bengtsson AA","Jonsen A","Gunnarsson I","Hamsten A","Syvanen AC","Strawbridge RJ","Sigurdsson S","Rantapaa-Dahlqvist S","Graham RR","Sturfelt G"],"additional_accession":[]},"is_claimable":false,"name":"A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.","description":"Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease in which the type I interferon pathway has a crucial role. We have previously shown that three genes in this pathway, IRF5, TYK2 and STAT4, are strongly associated with risk for SLE. Here, we investigated 78 genes involved in the type I interferon pathway to identify additional SLE susceptibility loci. First, we genotyped 896 single-nucleotide polymorphisms in these 78 genes and 14 other candidate genes in 482 Swedish SLE patients and 536 controls. Genes with P<0.01 in the initial screen were then followed up in 344 additional Swedish patients and 1299 controls. SNPs in the IKBKE, TANK, STAT1, IL8 and TRAF6 genes gave nominal signals of association with SLE in this extended Swedish cohort. To replicate these findings we ex","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Apr","modification":"2026-05-29T16:24:39.439Z","creation":"2019-03-27T00:39:52Z"},"accession":"S-EPMC3060320","cross_references":{"pubmed":["21179067"],"doi":["10.1038/ejhg.2010.197"]}}