{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zivkovic AM"],"funding":["NICHD NIH HHS","NIEHS NIH HHS"],"pagination":["4653-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3063602"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108 Suppl 1"],"pubmed_abstract":["Human milk contains an unexpected abundance and diversity of complex oligosaccharides apparently indigestible by the developing infant and instead targeted to its cognate gastrointestinal microbiota. Recent advances in mass spectrometry-based tools have provided a view of the oligosaccharide structures produced in milk across stages of lactation and among human mothers. One postulated function for these oligosaccharides is to enrich a specific \"healthy\" microbiota containing bifidobacteria, a genus commonly observed in the feces of breast-fed infants. Isolated culture studies indeed show selective growth of infant-borne bifidobacteria on milk oligosaccharides or core components therein. Parallel glycoprofiling documented that numerous Bifidobacterium longum subsp. infantis strains preferentially consume small mass oligosaccharides that are abundant early in the lactation cycle. Genome sequencing of numerous B. longum subsp. infantis strains shows a bias toward genes required to use mammalian-derived carbohydrates by comparison with adult-borne bifidobacteria. This intriguing strategy of mammalian lactation to selectively nourish genetically compatible bacteria in infants with a complex array of free oligosaccharides serves as a model of how to influence the human supraorganismal system, which includes the gastrointestinal microbiota."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Human milk glycobiome and its impact on the infant gastrointestinal microbiota."],"pmcid":["PMC3063602"],"funding_grant_id":["R01 ES002710","R01 HD061923","R01 HD059127","P42 ES02710","1R01HD061923","P01 ES011269","R37 ES002710","5R01HD059127","P01 ES11269"],"pubmed_authors":["Lebrilla CB","German JB","Zivkovic AM","Mills DA"],"additional_accession":[]},"is_claimable":false,"name":"Human milk glycobiome and its impact on the infant gastrointestinal microbiota.","description":"Human milk contains an unexpected abundance and diversity of complex oligosaccharides apparently indigestible by the developing infant and instead targeted to its cognate gastrointestinal microbiota. Recent advances in mass spectrometry-based tools have provided a view of the oligosaccharide structures produced in milk across stages of lactation and among human mothers. One postulated function for these oligosaccharides is to enrich a specific \"healthy\" microbiota containing bifidobacteria, a genus commonly observed in the feces of breast-fed infants. Isolated culture studies indeed show selective growth of infant-borne bifidobacteria on milk oligosaccharides or core components therein. Parallel glycoprofiling documented that numerous Bifidobacterium longum subsp. infantis strains preferentially consume small mass oligosaccharides that are abundant early in the lactation cycle. Genome sequencing of numerous B. longum subsp. infantis strains shows a bias toward genes required to use mammalian-derived carbohydrates by comparison with adult-borne bifidobacteria. This intriguing strategy of mammalian lactation to selectively nourish genetically compatible bacteria in infants with a complex array of free oligosaccharides serves as a model of how to influence the human supraorganismal system, which includes the gastrointestinal microbiota.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2021-02-20T05:35:59Z","creation":"2019-03-27T00:39:59Z"},"accession":"S-EPMC3063602","cross_references":{"pubmed":["20679197"],"doi":["10.1073/pnas.1000083107"]}}