{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(1)"],"submitter":["Sarup P"],"pubmed_abstract":["We investigated correlated responses in the transcriptomes of longevity-selected lines of Drosophila melanogaster to identify pathways that affect life span in metazoan systems. We evaluated the gene expression profile in young, middle-aged, and old male flies, finding that 530 genes were differentially expressed between selected and control flies when measured at the same chronological age. The longevity-selected flies consistently showed expression profiles more similar to control flies one age class younger than control flies of the same age. This finding is in accordance with a younger gene expression profile in longevity-selected lines. Among the genes down-regulated in longevity-selected lines, we found a clear over-representation of genes involved in immune functions, supporting the"],"journal":["Age (Dordrecht, Netherlands)"],"pagination":["69-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3063640"],"repository":["biostudies-literature"],"pubmed_title":["Flies selected for longevity retain a young gene expression profile."],"pmcid":["PMC3063640"],"pubmed_authors":["Sarup P","Loeschcke V","Sorensen P"],"additional_accession":[]},"is_claimable":false,"name":"Flies selected for longevity retain a young gene expression profile.","description":"We investigated correlated responses in the transcriptomes of longevity-selected lines of Drosophila melanogaster to identify pathways that affect life span in metazoan systems. We evaluated the gene expression profile in young, middle-aged, and old male flies, finding that 530 genes were differentially expressed between selected and control flies when measured at the same chronological age. The longevity-selected flies consistently showed expression profiles more similar to control flies one age class younger than control flies of the same age. This finding is in accordance with a younger gene expression profile in longevity-selected lines. Among the genes down-regulated in longevity-selected lines, we found a clear over-representation of genes involved in immune functions, supporting the","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-05-29T20:57:01.819Z","creation":"2025-05-29T20:57:01.819Z"},"accession":"S-EPMC3063640","cross_references":{"pubmed":["20607427"],"doi":["10.1007/s11357-010-9162-8"]}}