biostudies-literatureUnknown33(1)Sarup PWe investigated correlated responses in the transcriptomes of longevity-selected lines of Drosophila melanogaster to identify pathways that affect life span in metazoan systems. We evaluated the gene expression profile in young, middle-aged, and old male flies, finding that 530 genes were differentially expressed between selected and control flies when measured at the same chronological age. The longevity-selected flies consistently showed expression profiles more similar to control flies one age class younger than control flies of the same age. This finding is in accordance with a younger gene expression profile in longevity-selected lines. Among the genes down-regulated in longevity-selected lines, we found a clear over-representation of genes involved in immune functions, supporting theAge (Dordrecht, Netherlands)69-80https://www.ebi.ac.uk/biostudies/studies/S-EPMC3063640biostudies-literatureFlies selected for longevity retain a young gene expression profile.PMC3063640Sarup PLoeschcke VSorensen PfalseFlies selected for longevity retain a young gene expression profile.We investigated correlated responses in the transcriptomes of longevity-selected lines of Drosophila melanogaster to identify pathways that affect life span in metazoan systems. We evaluated the gene expression profile in young, middle-aged, and old male flies, finding that 530 genes were differentially expressed between selected and control flies when measured at the same chronological age. The longevity-selected flies consistently showed expression profiles more similar to control flies one age class younger than control flies of the same age. This finding is in accordance with a younger gene expression profile in longevity-selected lines. Among the genes down-regulated in longevity-selected lines, we found a clear over-representation of genes involved in immune functions, supporting the2011-01-01T00:00:00Z2011 Mar2025-05-29T20:57:01.819Z2025-05-29T20:57:01.819ZS-EPMC30636402060742710.1007/s11357-010-9162-8