{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gordon SN"],"funding":["Intramural NIH HHS","NCRR NIH HHS","NIAID NIH HHS"],"pagination":["1043-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3068024"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["203(8)"],"pubmed_abstract":["The licensed smallpox vaccine, ACAM2000, is a cell culture derivative of Dryvax. Both ACAM2000 and Dryvax are administered by skin scarification and can cause progressive vaccinia, with skin lesions that disseminate to distal sites. We have investigated the immunologic basis of the containment of vaccinia in the skin with the goal to identify safer vaccines for smallpox. Macaques were depleted systemically of T or B cells and vaccinated with either Dryvax or an attenuated vaccinia vaccine, LC16m8. B cell depletion did not affect the size of skin lesions induced by either vaccine. However, while depletion of both CD4(+) and CD8(+) T cells had no adverse effects on LC16m8-vaccinated animals, it caused progressive vaccinia in macaques immunized with Dryvax. As both Dryvax and LC16m8 vaccines "],"journal":["The Journal of infectious diseases"],"pubmed_title":["Smallpox vaccine safety is dependent on T cells and not B cells."],"pmcid":["PMC3068024"],"funding_grant_id":["Z01 BC005688-18","P30 AI060354","R24 RR016001"],"pubmed_authors":["McNally J","Hryniewicz A","Chung HK","Shinmura Y","Reimann KA","Venzon D","Kanehara T","Franchini G","Cecchinato V","Parks RW","Silvera P","Heraud JM","Karpova T","Andresen V","Gordon SN","Yokote H","Matsui H"],"additional_accession":[]},"is_claimable":false,"name":"Smallpox vaccine safety is dependent on T cells and not B cells.","description":"The licensed smallpox vaccine, ACAM2000, is a cell culture derivative of Dryvax. Both ACAM2000 and Dryvax are administered by skin scarification and can cause progressive vaccinia, with skin lesions that disseminate to distal sites. We have investigated the immunologic basis of the containment of vaccinia in the skin with the goal to identify safer vaccines for smallpox. Macaques were depleted systemically of T or B cells and vaccinated with either Dryvax or an attenuated vaccinia vaccine, LC16m8. B cell depletion did not affect the size of skin lesions induced by either vaccine. However, while depletion of both CD4(+) and CD8(+) T cells had no adverse effects on LC16m8-vaccinated animals, it caused progressive vaccinia in macaques immunized with Dryvax. As both Dryvax and LC16m8 vaccines ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Apr","modification":"2025-04-22T06:48:04.32Z","creation":"2019-03-27T00:40:15Z"},"accession":"S-EPMC3068024","cross_references":{"pubmed":["21450994"],"doi":["10.1093/infdis/jiq162"]}}