{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Berger SI"],"funding":["NIDDK NIH HHS","NCRR NIH HHS","NIGMS NIH HHS"],"pagination":["ra30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3068558"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(118)"],"pubmed_abstract":["Long QT syndrome (LQTS) is a congenital or drug-induced change in electrical activity of the heart that can lead to fatal arrhythmias. Mutations in 12 genes encoding ion channels and associated proteins are linked with congenital LQTS. With a computational systems biology approach, we found that gene products involved in LQTS formed a distinct functional neighborhood within the human interactome. Other diseases form similarly selective neighborhoods, and comparison of the LQTS neighborhood with other disease-centered neighborhoods suggested a molecular basis for associations between seemingly unrelated diseases that have increased risk of cardiac complications. By combining the LQTS neighborhood with published genome-wide association study data, we identified previously unknown single-nucl"],"journal":["Science signaling"],"pubmed_title":["Systems pharmacology of arrhythmias."],"pmcid":["PMC3068558"],"funding_grant_id":["DK038761","P50 GM071558","T32 GM062754","UL1RR029887","P50GM07558","UL1 RR029887","R01 DK038761","GM062754"],"pubmed_authors":["Iyengar R","Berger SI","Ma'ayan A"],"additional_accession":[]},"is_claimable":false,"name":"Systems pharmacology of arrhythmias.","description":"Long QT syndrome (LQTS) is a congenital or drug-induced change in electrical activity of the heart that can lead to fatal arrhythmias. Mutations in 12 genes encoding ion channels and associated proteins are linked with congenital LQTS. With a computational systems biology approach, we found that gene products involved in LQTS formed a distinct functional neighborhood within the human interactome. Other diseases form similarly selective neighborhoods, and comparison of the LQTS neighborhood with other disease-centered neighborhoods suggested a molecular basis for associations between seemingly unrelated diseases that have increased risk of cardiac complications. By combining the LQTS neighborhood with published genome-wide association study data, we identified previously unknown single-nucl","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2026-05-05T06:14:12.058Z","creation":"2019-03-27T00:40:16Z"},"accession":"S-EPMC3068558","cross_references":{"pubmed":["20407125"],"doi":["10.1126/scisignal.2000723"]}}