{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["108(13)"],"submitter":["McGlinchey RP"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["[PSI(+)] is a prion of the essential translation termination factor Sup35p. Although mammalian prion infections are uniformly fatal, commonly studied [PSI(+)] variants do not impair growth, leading to suggestions that [PSI(+)] may protect against stress conditions. We report here that over half of [PSI(+)] variants are sick or lethal. These \"killer [PSI(+)]s\" are compatible with cell growth only when also expressing minimal Sup35C, lacking the N-terminal prion domain. The severe detriment of killer [PSI(+)] results in rapid selection of nonkiller [PSI(+)] variants or loss of the prion. We also report variants of [URE3], a prion of the nitrogen regulation protein Ure2p, that grow much slower than ure2Δ cells. Our findings give a more realistic picture of the impact of the prion change than "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["5337-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3069153"],"repository":["biostudies-literature"],"pubmed_title":["Suicidal [PSI+] is a lethal yeast prion."],"pmcid":["PMC3069153"],"pubmed_authors":["Wickner RB","Kryndushkin D","McGlinchey RP"],"additional_accession":[]},"is_claimable":false,"name":"Suicidal [PSI+] is a lethal yeast prion.","description":"[PSI(+)] is a prion of the essential translation termination factor Sup35p. Although mammalian prion infections are uniformly fatal, commonly studied [PSI(+)] variants do not impair growth, leading to suggestions that [PSI(+)] may protect against stress conditions. We report here that over half of [PSI(+)] variants are sick or lethal. These \"killer [PSI(+)]s\" are compatible with cell growth only when also expressing minimal Sup35C, lacking the N-terminal prion domain. The severe detriment of killer [PSI(+)] results in rapid selection of nonkiller [PSI(+)] variants or loss of the prion. We also report variants of [URE3], a prion of the nitrogen regulation protein Ure2p, that grow much slower than ure2Δ cells. Our findings give a more realistic picture of the impact of the prion change than ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-21T21:17:19.815Z","creation":"2019-03-27T00:40:17Z"},"accession":"S-EPMC3069153","cross_references":{"pubmed":["21402947"],"doi":["10.1073/pnas.1102762108"]}}