{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alexander D"],"funding":["NHLBI NIH HHS"],"pagination":["527-38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3071865"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(5)"],"pubmed_abstract":["<h4>Background</h4>Metabolomics, the comprehensive profile of small-molecule metabolites found in biological specimens, has the potential to provide insights into the pathogenesis of disease states and lead to the identification of new biomarkers.<h4>Methods and results</h4>We analysed 451 plasma metabolites by liquid chromatography/mass spectroscopy and gas chromatography/mass spectroscopy in 39 patients with primary dilated cardiomyopathy (DCM) and 31 age-, sex- and body mass index-matched controls. Sixty-one metabolites were significantly different between primary DCM and control individuals [false discovery rate (FDR) < 0·05]. Plasma levels of steroid metabolites, glutamine, threonine and histidine were reduced while levels of citric acid cycle intermediates and lipid β-oxidation produ"],"journal":["European journal of clinical investigation"],"pubmed_title":["Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy."],"pmcid":["PMC3071865"],"funding_grant_id":["R01 HL068884-05","R01 HL068884","R01 HL088498","R01 HL088498-03"],"pubmed_authors":["Rodriguez G","Marian AJ","Alexander D","Lombardi R","Mitchell MM"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy.","description":"<h4>Background</h4>Metabolomics, the comprehensive profile of small-molecule metabolites found in biological specimens, has the potential to provide insights into the pathogenesis of disease states and lead to the identification of new biomarkers.<h4>Methods and results</h4>We analysed 451 plasma metabolites by liquid chromatography/mass spectroscopy and gas chromatography/mass spectroscopy in 39 patients with primary dilated cardiomyopathy (DCM) and 31 age-, sex- and body mass index-matched controls. Sixty-one metabolites were significantly different between primary DCM and control individuals [false discovery rate (FDR) < 0·05]. Plasma levels of steroid metabolites, glutamine, threonine and histidine were reduced while levels of citric acid cycle intermediates and lipid β-oxidation produ","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2025-04-04T23:07:13.922Z","creation":"2019-03-27T00:40:25Z"},"accession":"S-EPMC3071865","cross_references":{"pubmed":["21155767"],"doi":["10.1111/j.1365-2362.2010.02441.x"]}}