{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Calvo AC"],"pubmed_abstract":["Background
Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurodegenerative diseases. Neurotrophic factors have been widely tested to counteract neurodegenerative conditions, despite their unspecific neuronal access. The non-toxic C-terminal fragment of the tetanus toxin (TTC) heavy chain has been studied not only as a carrier molecule to the CNS but also as a neuroprotective agent. Because the neurotrophic effects of BDNF have been demonstrated in vitro and in vivo, the question addressed in this work is whether a fusion molecule of BDNF-TTC may have a synergistic effect and enhance the neuroprotective properties of TTC alone in a mouse model of ALS.Methods
Recombinant plasmid constructs (pCMV-TTC and pCMV-BDNF-TTC) were injected into the quadriceps fem"],"journal":["Orphanet journal of rare diseases"],"pagination":["10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3072305"],"repository":["biostudies-literature"],"pubmed_title":["Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule."],"pmcid":["PMC3072305"],"pubmed_authors":["Moreno-Igoa M","Munoz MJ","Mancuso R","Calvo AC","Navarro X","Penas C","Manzano R","Osta R","Olivan S","Zaragoza P"],"additional_accession":[]},"is_claimable":false,"name":"Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule.","description":"Background
Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurodegenerative diseases. Neurotrophic factors have been widely tested to counteract neurodegenerative conditions, despite their unspecific neuronal access. The non-toxic C-terminal fragment of the tetanus toxin (TTC) heavy chain has been studied not only as a carrier molecule to the CNS but also as a neuroprotective agent. Because the neurotrophic effects of BDNF have been demonstrated in vitro and in vivo, the question addressed in this work is whether a fusion molecule of BDNF-TTC may have a synergistic effect and enhance the neuroprotective properties of TTC alone in a mouse model of ALS.Methods
Recombinant plasmid constructs (pCMV-TTC and pCMV-BDNF-TTC) were injected into the quadriceps fem","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2025-04-20T02:20:31.11Z","creation":"2021-02-20T00:53:54Z"},"accession":"S-EPMC3072305","cross_references":{"pubmed":["21418619"],"doi":["10.1186/1750-1172-6-10"]}}