{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brichacek M"],"funding":["NIGMS NIH HHS"],"pagination":["1110-3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3072884"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["In this report, it is demonstrated that chiral vinyl aziridines can be stereospecifically ring expanded. This synthetic approach allows controlled access to chiral 2,5-cis- or 2,5-trans-3-pyrroline products from starting materials with the appropriate aziridine geometry. Twenty three ring expansion examples, most of which feature a stereospecific cyclization, are presented."],"journal":["Organic letters"],"pubmed_title":["Stereospecific ring expansion of chiral vinyl aziridines."],"pmcid":["PMC3072884"],"funding_grant_id":["T32GM008500","T32 GM008500-11","T32 GM008500"],"pubmed_authors":["Brichacek M","Njardarson JT","Villalobos MN","Plichta A"],"additional_accession":[]},"is_claimable":false,"name":"Stereospecific ring expansion of chiral vinyl aziridines.","description":"In this report, it is demonstrated that chiral vinyl aziridines can be stereospecifically ring expanded. This synthetic approach allows controlled access to chiral 2,5-cis- or 2,5-trans-3-pyrroline products from starting materials with the appropriate aziridine geometry. Twenty three ring expansion examples, most of which feature a stereospecific cyclization, are presented.","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 Mar","modification":"2020-11-01T08:15:35Z","creation":"2019-03-27T00:40:29Z"},"accession":"S-EPMC3072884","cross_references":{"pubmed":["21309528"],"doi":["10.1021/ol200263g"]}}