{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kohwi M"],"funding":["NICHD NIH HHS","Howard Hughes Medical Institute"],"pagination":["1727-35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3074449"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["138(9)"],"pubmed_abstract":["A fundamental question in brain development is how precursor cells generate a diverse group of neural progeny in an ordered manner. Drosophila neuroblasts sequentially express the transcription factors Hunchback (Hb), Krüppel (Kr), Pdm1/Pdm2 (Pdm) and Castor (Cas). Hb is necessary and sufficient to specify early-born temporal identity and, thus, Hb downregulation is essential for specification of later-born progeny. Here, we show that distal antenna (dan) and distal antenna-related (danr), encoding pipsqueak motif DNA-binding domain protein family members, are detected in all neuroblasts during the Hb-to-Cas expression window. Dan and Danr are required for timely downregulation of Hb in neuroblasts and for limiting the number of early-born neurons. Dan and Danr function independently of Se"],"journal":["Development (Cambridge, England)"],"pubmed_title":["The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity."],"pmcid":["PMC3074449"],"funding_grant_id":["R01 HD027056","HD27056","R37 HD027056"],"pubmed_authors":["Doe CQ","Hiebert LS","Kohwi M"],"additional_accession":[]},"is_claimable":false,"name":"The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity.","description":"A fundamental question in brain development is how precursor cells generate a diverse group of neural progeny in an ordered manner. Drosophila neuroblasts sequentially express the transcription factors Hunchback (Hb), Krüppel (Kr), Pdm1/Pdm2 (Pdm) and Castor (Cas). Hb is necessary and sufficient to specify early-born temporal identity and, thus, Hb downregulation is essential for specification of later-born progeny. Here, we show that distal antenna (dan) and distal antenna-related (danr), encoding pipsqueak motif DNA-binding domain protein family members, are detected in all neuroblasts during the Hb-to-Cas expression window. Dan and Danr are required for timely downregulation of Hb in neuroblasts and for limiting the number of early-born neurons. Dan and Danr function independently of Se","dates":{"release":"2011-01-01T00:00:00Z","publication":"2011 May","modification":"2025-04-18T14:34:19.537Z","creation":"2019-03-27T00:40:33Z"},"accession":"S-EPMC3074449","cross_references":{"pubmed":["21429984"],"doi":["10.1242/dev.061499"]}}