{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Terry KL"],"funding":["NCI NIH HHS"],"pagination":["272-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC3076782"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(4)"],"pubmed_abstract":["Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) = 1.06-1.77) in one study "],"journal":["International journal of molecular epidemiology and genetics"],"pubmed_title":["A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies."],"pmcid":["PMC3076782"],"funding_grant_id":["N01 CN025403","R01 CA058598","R01 CA054419"],"pubmed_authors":["Cramer DW","Terry KL","Titus-Ernstoff L","Gayther SA","Pharaoh PD","Song H","Goodman MT","Vitonis AF","Wilkens LR","Menon U","Lurie G","Carney ME","Ramus SJ","Gentry-Maharaj A","Birrer MJ","Hernandez D"],"additional_accession":[]},"is_claimable":false,"name":"A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies.","description":"Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) = 1.06-1.77) in one study ","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jul","modification":"2025-04-21T19:13:30.97Z","creation":"2019-03-27T00:40:40Z"},"accession":"S-EPMC3076782","cross_references":{"pubmed":["21532840"]}}